Medical Instrument Compatible Disinfectant Generator

医疗器械兼容消毒剂发生器

• 批准号: 7326234
• 负责人: ANJAL C SHARMA
• 金额: $ 47.21万
• 依托单位: LYNNTECH, INC.
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-15 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7326234
• 关键词: Acetic Acid; Acetic Acids; Acids; Address; Aluminum; Animals; Award; Back; Bacteria; Bacterial Spores; Benign; Biocide; Biological Preservation; Breathing; Capital; Caring; Cells; Chemicals; Chlorine; Citric Acid; Collaborations; Colonoscopes; Communities; Compatible; Condition; Construction Materials; Consultations; Corrosion; Corrosives; Cross Infection; Custom; Cyst; Data; Detection; Development; Devices; Diagnostic Procedure; Disinfectants; Disinfection; Dose; Drops; Drug Formulations; Effectiveness; Electrolyses; Emerging Technologies; Emulsions; Endoscopes; Environment; Equilibrium; Equipment; Ethylene Oxide; Evaluation; Excision; Exposure to; Facility Construction Funding Category; Food; Foundations; Frequencies; Funding; Gases; Generations; Germicide; Glutaral; Goals; Government; Health; Health Professional; High temperature of physical object; Hospitals; Hour; Human; Hydrocarbons; Hydrogen Peroxide; Hydrolysis; Hypochlorite; Hypochlorous Acid; Hypochlorous Acids; Hysteroscopes; In Situ; Industrial fungicide; Industry; Intervention; Invasive; Investments; Irritants; Joints; Laparoscopes; Legal patent; Letters; Licensing; Life; Liquid substance; Maintenance; Manufacturer Name; Marketing; Materials Testing; Measures; Medical; Medical Device; Medical center; Medicine; Membrane; Metabolic; Methods; Microbe; Microbial Biofilms; Monitor; Motivation; Names; Numbers; Operating System; Operative Surgical Procedures; Oxidants; Parents; Patients; Peracetic Acid; Performance; Peroxides; Persons; Phase; Phase I Clinical Trials; Poison; Powder dose form; Preparation; Procedures; Process; Production; Property; Publications; Purpose; Range; Rate; Reproduction spores; Research; Research Personnel; Resistance; Safety; Salts; Sodium Chloride; Sodium Hypochlorite; Solutions; Sterilization for infection control; Sterilox; Surgical Instruments; System; Techniques; Technology; Test Result; Testing; Texas; Time; Toxic effect; Toxin; Transportation; Ultrasonics; United States Environmental Protection Agency; United States Food and Drug Administration; Universities; Virus; Water; Water Purification; Work; antimicrobial; aqueous; bacterial resistance; bactericide; base; chlorine dioxide; commercialization; concept; cost; cost effective; design; desire; detector; direct application; disease transmission; dosage; food preparation; food sanitation; fungus; hazard; inhibitor/antagonist; innovation; instrument; interest; killings; medical food; medical schools; microbial; microorganism; new technology; novel; occupational hazard; pressure; prevent; prototype; skills; sodium chlorite; sodium sulfate; success; superoxidized water; technology development; trend; user-friendly; vapor; virucide

DESCRIPTION (provided by applicant): Lynntech, Inc in collaboration with a reputed medical school proposes the development of an automated, on- demand, electrochemical generator of chlorine dioxide for a variety of high level disinfection applications, including endoscope reprocessing and surgical instrument disinfection. During the Phase I project, Lynntech has already demonstrated the construction and reliable operation of a bench scale automated device which can deliver desired levels of chlorine dioxide in a rapid manner. Lynntech's electrochemically generated chlorine dioxide solutions have been demonstrated to be as effective a disinfectant as commercially available presently used peracetic acid based high level disinfectants. In addition, Lynntech's electrochemically generated chlorine dioxide solutions have been shown to be compatible with a wide variety of medically relevant materials, and in certain cases, significantly less corrosive to medical materials than the widely used peracetic acid based disinfectants. Since complete proof-of-concept for Lynntech's automated electrochemical chlorine dioxide generator has been provided in the Phase I project, this proposed follow on Phase II effort specifically aims to develop a prototype compact device for automated medical device (endoscopes and surgical instruments) reprocessing. The device proposed herein will be fabricated, automated and tested upon retrofitting to a commercially available automated endoscope reprocessor for reliable operation in consultation with a reputed medical school. We will also perform exhaustive testing of the efficacy of the chlorine dioxide generator for low corrosion disinfection of actual surgical instruments and endoscopes during this Phase II effort. We will showcase our device and its operation to large manufacturers of automated endoscope reprocessors. Based on their input we will gear the technology to be commercially attractive to facilitate commercialization beyond Phase II in collaboration with these manufacturers, through either joint development, spin off company formation or outright licensing scenarios. The development of our low cost, fast acting and safe automated chlorine dioxide generator based automated reprocessor device will enable the production of high performance disinfecting solution for reliable medical instrument reprocessing. This will certainly reduce health professional exposure to toxic chemicals and decrease the cost of medical instrument reprocessing. In addition, the hundreds of thousands of patients who undergo endoscopic or surgical procedures annually will be adequately protected against cross infection through the availability of our automated medical instrument reprocessor. The financial benefits to existing automated reprocessing unit manufacturers who can simply modify their existing devices to incorporate the electrochemical chlorine dioxide production technology will therefore be immense.

描述（由申请人提供）：Lynntech，Inc与一所知名医学院合作，提出开发一种自动化、按需、电化学二氧化氯发生器，用于各种高水平消毒应用，包括内窥镜再处理和手术器械消毒。在第一阶段项目中，Lynntech已经展示了一个实验室规模的自动化设备的建造和可靠运行，该设备可以快速提供所需水平的二氧化氯。Lynntech的电化学产生的二氧化氯溶液已被证明是有效的消毒剂作为市售目前使用的过氧乙酸为基础的高水平消毒剂。此外，Lynntech的电化学产生的二氧化氯溶液已被证明与各种医疗相关材料兼容，在某些情况下，对医疗材料的腐蚀性明显低于广泛使用的过氧乙酸消毒剂。由于Lynntech的自动电化学二氧化氯发生器的完整概念验证已在第一阶段项目中提供，因此，该拟议的第二阶段后续工作专门旨在开发用于自动医疗器械（内窥镜和手术器械）再处理的原型紧凑型器械。本文提出的器械将在改装到市售自动内窥镜洗消机后进行制造、自动化和测试，以便与知名医学院协商可靠运行。在第二阶段的工作中，我们还将对二氧化氯发生器对实际手术器械和内窥镜进行低腐蚀消毒的有效性进行详尽的测试。我们将向自动内窥镜再处理机的大型制造商展示我们的设备及其操作。根据他们的投入，我们将通过联合开发、分拆公司或直接许可方案，使该技术在商业上具有吸引力，以促进与这些制造商合作的第二阶段之后的商业化。我们开发的低成本、快速作用和安全的基于自动化二氧化氯发生器的自动化洗消设备将能够生产高性能的消毒溶液，用于可靠的医疗器械洗消。这肯定会减少卫生专业人员接触有毒化学品，并降低医疗器械再处理的成本。此外，每年接受内窥镜或外科手术的数十万患者将通过我们的自动医疗器械再处理器的可用性得到充分保护，免受交叉感染。因此，对现有的自动化后处理装置制造商来说，只要简单地修改其现有设备以纳入电化学二氧化氯生产技术，其经济效益将是巨大的。