iCAP An Innovative Device to Rapidly Resolve Microbial Keratitis
iCAP An Innovative Device to Rapidly Resolve Microbial Keratitis
批准号:
9135879
负责人:
ANJAL C SHARMA
金额:
$23.65万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-09-30 至 2019-09-30
关键词:
Accident and Emergency departmentAccountingAdhesionsAmbulatory Care FacilitiesAmoeba genusAntibiotic ResistanceAntibioticsAntimicrobial susceptibilityAreaArgonBacteriaBacterial ModelBlindnessCataractCell Culture TechniquesCell ProliferationChemical ExposureCicatrixClinicalCoagulaseCodeCollaborationsCorneaCorneal UlcerCorneal edemaCoupledDNA DamageDataDatabasesDefectDevicesDiagnosisDiseaseDistressEdemaEmergency SituationEmergency department visitEndophthalmitisEngineeringEnsureEpidermal Growth Factor ReceptorExpenditureEyeFocal AdhesionsFutureGasesGenus staphylococcusHealedHealth ExpendituresHealthcareHealthcare SystemsHeliumHourHydrogen PeroxideIL8 geneIn VitroInfectionInflammationInterleukin-6KeratitisKeratoplastyLeadLegal BlindnessLightLipid PeroxidationMammalian CellMedicalMedical centerMembrane LipidsMethodsMicrobeMississippiModelingNatural regenerationNitrogenOphthalmologistOryctolagus cuniculusOutcomeOxygenPTK2 genePatientsPenetrating KeratoplastyPerforationPerformancePhasePhysiologic Intraocular PressurePlasmaPopulationPseudomonas aeruginosaRegulationResolutionSafetySignal PathwaySmall Business Innovation Research GrantStagingStaphylococcus aureusStreptococcusStreptococcus pneumoniaeTimeTraumaTreatment CostUniversitiesVinculinVirusWeightcommercializationcorneal repaircytokinedesignefficacy evaluationfungushealingimprovedin vivoin vivo Modelinnovationkillingsmicrobialmigrationpre-clinicalprototypepublic health relevanceregenerativerepairedresistance mechanismtechnology development
中文摘要
英文摘要
DESCRIPTION (provided by applicant): Ulcerative keratitis caused by infectious microbes (bacteria, fungi, amoebae and viruses) represents a major area of medical concern. It is one of the most important causes of corneal opacifications, which is the second common cause of legal blindness world-wide after cataracts. In 2010, in the USA alone, 76.5% of the approximately 930,000 doctor's office and outpatient clinic and 58,000 emergency department visits related to ocular distress and emergencies, resulted in antibiotic prescriptions for microbil keratitis. The total annual financial burden on our healthcare system for keratitis cases was estimated to be $175 million in direct health care expenditures in 2010 and was also estimated to consume over 250,000 annual hours of clinician time. Bacterial keratitis manifests as corneal ulcer, corneal edema and/or hypopyon and can cause significant complications including corneal perforation, corneal thinning, elevated intraocular pressure and progression to endophthalmitis. This could lead to severe clinical outcomes including partial or complete vision loss, necessity for penetrating keratoplasty, corneal grafts, enucleation and evisceration. Although topical and systemic antibiotics are effective in reducing microbial loads in keratitis cases (unless the microbe is resistant to the antibiotic utilized), the time required to resolve th infection is generally quite lengthy. Furthermore, antibiotics are typically ineffective in reducin inflammation and evoking regenerative repair of corneal and/or scleral defects and scarring which may be induced by the infection. Lynntech, Inc. in collaboration with the University of Mississippi Medical Center proposes to develop an innovative, inexpensive and compact device, termed iCAP to effectively treat microbial keratitis at the point-of-diagnosis. This device
will be engineered to rapidly and reagentlessly significantly reduce or totally eliminate bacterial
loads regardless of antimicrobial susceptibility status of the infecting microbial species. Furthermore, iCAP has the potential to simultaneously trigger certain cellular signaling pathways which could result in improved regeneration of corneal and scleral defects induced by the infection. During this Phase I SBIR effort, our specific aims are to (1) design and fabricate prototype iCAP devices, (2) utilize in vitro microbial and mammalian cell culture techniques to obtain pilot ranges of iCAP device operating parameters likely to be effective in vivo and (3) demonstrate that iCAP can significantly reduce or eliminate bacterial loads and orchestrate healing of infection induced corneal/scleral defects in a relevant in vivo rabbit eye model of bacterial keratitis. The successful completion of these specific aims should demonstrate ample feasibility of this innovative new microbial keratitis treatment approach, and will enable us to execute more comprehensive technology development and commercialization thrusts in a future follow-on Phase II effort. The eventual commercial availability of iCAP devices is likely to sustai high positive impact for the patient populace suffering from microbial keratitis.
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