Deep Brain Stimulation Array for Neuromodulation

用于神经调节的深部脑刺激阵列

基本信息

  • 批准号:
    7325583
  • 负责人:
  • 金额:
    $ 24.03万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-08-01 至 2008-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Chronic Deep Brain Stimulation (DBS) emerged in the last decade as a revolutionary new approach to the treatment of neurological and psychiatric disorders. DBS is currently approved for treatment of Parkinson's Disease (PD) and Essential Tremor and is showing promise for treatment of dystonia, intractable epilepsy, major depression, and obsessive-compulsive disorder. DBS therapy involves controllable electrical stimulation through a lead having four relatively large electrodes that implanted in the targeted region of the thalamus or basal ganglia. While DBS therapy is generally safe and effective for reducing cardinal symptoms of the approved diseases, it often has significant behavioral and cognitive side effects and limits on performance. Additionally, experimental and computational studies have revealed complex mechanisms of action for specific disease states. The growing body of clinical and scientific evidence strongly suggests that details such as fine electrode positioning, selectivity, and precise stimulation patterning are very important for clinical outcomes. The proposed Deep Brain Stimulating Array (or DBSA) is an electrode array designed for long-term stimulation and is comprised of many microelectrode sites, therefore providing significantly enhanced stimulation selectivity, precision, and tunability. The technical innovation of this device is the use of a large number of smaller sites (64 sites) that can be used individually or in selectable groups in order to achieve more diverse electrical stimulation patterns. This array of sites will significantly expand the tunable range of the device in order to better fit the DBS therapy to the patient. It will also provide the capability of incorporating feedback control through neural recordings (32 sites) for eventual on-demand DBS, similar to that of modern cardiac pacemakers. The specific goals of this SBIR Phase I proposal are to develop a prototype version of the DBSA and to evaluate its feasibility for selective and tunable DBS therapy. The prototype DBSA will be used to evaluate critical packaging, materials, and functional attributes of the device. The first specific aim is to develop a prototype DBSA, with the expected outcome of this aim being a validated first generation prototype device. The second specific aim is to evaluate the electrical stimulation characteristics of the DBSA. The expected outcome of this aim will be an analytical and experimental analysis of the stimulation capabilities of the DBSA. The third specific aim is to evaluate the chronic tissue reactions to the DBSA. The expected outcomes of this aim are preliminary data on the safety and biocompatibility of the chosen materials, geometrical specifications and stimulation protocols. NeuroNexus is leading this project in collaboration with FHC, the University of Michigan and consultants from the Cleveland Clinic. The multi-disciplinary project team possesses the experience, skill sets, and resources to meet the project goals and, in the process, to move the field of neural engineering ahead. The primary objective of this project is the development of an advanced electrode technology used for deep brain stimulation (DBS) therapy. DBS is a common therapeutic approach for the treatment of Parkinson's Disease, and potentially other movement related disorders.
描述(由申请人提供):慢性深部脑刺激(DBS)在过去十年中出现,作为治疗神经和精神疾病的革命性新方法。 DBS 目前已被批准用于治疗帕金森病 (PD) 和原发性震颤,并在治疗肌张力障碍、顽固性癫痫、重度抑郁症和强迫症方面显示出前景。 DBS 疗法涉及通过植入丘脑或基底神经节目标区域的具有四个相对较大电极的导线进行可控电刺激。虽然 DBS 疗法对于减少已批准疾病的主要症状通常是安全有效的,但它通常具有显着的行为和认知副作用以及对表现的限制。此外,实验和计算研究揭示了特定疾病状态的复杂作用机制。越来越多的临床和科学证据强烈表明,精细电极定位、选择性和精确刺激模式等细节对于临床结果非常重要。所提出的深部脑刺激阵列(或 DBSA)是一种专为长期刺激而设计的电极阵列,由许多微电极位点组成,因此可显着增强刺激的选择性、精度和可调谐性。该设备的技术创新在于使用大量较小的站点(64个站点),这些站点可以单独使用或分组使用,以实现更多样化的电刺激模式。这一系列位点将显着扩大设备的可调范围,以便更好地适应患者的 DBS 治疗。它还将提供通过神经记录(32 个站点)合并反馈控制的能力,以实现最终的按需 DBS,类似于现代心脏起搏器。 SBIR 第一阶段提案的具体目标是开发 DBSA 的原型版本,并评估其选择性和可调节 DBS 治疗的可行性。 DBSA 原型将用于评估设备的关键包装、材料和功能属性。第一个具体目标是开发原型 DBSA,该目标的预期结果是经过验证的第一代原型设备。第二个具体目标是评估 DBSA 的电刺激特性。这一目标的预期结果将是对 DBSA 的增产能力进行分析和实验分析。第三个具体目标是评估 DBSA 的慢性组织反应。该目标的预期结果是有关所选材料、几何规格和刺激方案的安全性和生物相容性的初步数据。 NeuroNexus 与 FHC、密歇根大学和克利夫兰诊所的顾问合作领导该项目。多学科项目团队拥有实现项目目标的经验、技能和资源,并在此过程中推动神经工程领域向前发展。该项目的主要目标是开发用于深部脑刺激(DBS)治疗的先进电极技术。 DBS 是治疗帕金森病和其他潜在运动相关疾病的常见治疗方法。

项目成果

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{{ truncateString('RIO J VETTER', 18)}}的其他基金

Deep Brain Stimulation Array for Neuromodulation
用于神经调节的深部脑刺激阵列
  • 批准号:
    8284317
  • 财政年份:
    2007
  • 资助金额:
    $ 24.03万
  • 项目类别:
Deep Brain Stimulation Array for Neuromodulation
用于神经调节的深部脑刺激阵列
  • 批准号:
    8514084
  • 财政年份:
    2007
  • 资助金额:
    $ 24.03万
  • 项目类别:
Deep Brain Stimulation Array for Neuromodulation
用于神经调节的深部脑刺激阵列
  • 批准号:
    8057777
  • 财政年份:
    2007
  • 资助金额:
    $ 24.03万
  • 项目类别:

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