Improved Sample Delivery Devices for NMR

改进的 NMR 样品输送装置

• 批准号: 7325580
• 负责人: Michael John Cavaluzzi
• 金额: $ 10.69万
• 依托单位: DRAGONFLY INNOVATION, LLC
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2010-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7325580
• 关键词: Air; Chemicals; Clinical Trials; Compatible; Development; Devices; Environment; Equipment; Laboratories; Liquid substance; Methodology; Methods; NMR Spectroscopy; Nuclear Magnetic Resonance; Performance; Phase; Plasticizers; Pliability; Preparation; Production; Protocols documentation; Purpose; Resistance; Risk; Safety; Sampling; Solvents; System; Time; Tube; Water; design; evaporation; hospital laboratories; improved; innovation; instrument; instrumentation; prototype; research study; seal

DESCRIPTION (provided by applicant): Alternative polymeric materials will be applied toward new products compatible with 5, 3, and 1-mm tubes used in liquid-state Nuclear Magnetic Resonance (NMR) spectroscopy. Each aim in phase I is directed towards developing viable prototypes to upgrade current experimental methodologies. Proposed devices used for NMR sample preparation and storage will a) improve long-term storage of samples b) alleviate the need for glovebox preparation manipulations c) allow for in-line sample/solvent delivery. Design enhancements should improve ease of use by increasing safety considerations and reducing sample loss risks. Phase II considerations will involve developing interface/adaptation components to fully integrate devices with instrumentation commonly found in chemical laboratories and hospital/clinical-trial environments. Priorities will focus on providing instrument flexibility using existing equipment to upgrade NMR sample preparation methods. This project seeks to develop sample preparation and storage devices used in Nuclear Magnetic Resonance spectroscopy that will cumulatively improve sample throughput efficiency and expand experimental protocols.

描述(由申请人提供)：替代聚合物材料将应用于与用于液态核磁共振(核磁共振)光谱分析的5、3和1 mm管兼容的新产品。第一阶段的每个目标都是为了开发可行的原型，以升级现有的实验方法。用于核磁共振样品制备和储存的拟议装置将a)改善样品的长期储存，b)减轻手套盒制备操作的需要，c)允许在线样品/溶剂输送。设计改进应通过增加安全考虑因素和降低样品丢失风险来提高易用性。第二阶段的考虑将涉及开发接口/适应组件，以将设备与化学实验室和医院/临床试验环境中常见的仪器完全整合在一起。优先事项将侧重于利用现有设备提供仪器灵活性，以升级核磁共振样品制备方法。该项目旨在开发用于核磁共振波谱学的样品制备和存储设备，以累积提高样品吞吐效率并扩展实验方案。