Development of a Pre-Hospital Ultra-Wide Band Radar Cardiac Function Monitor

院前超宽带雷达心功能监测仪的研制

• 批准号: 7273954
• 负责人: GREGORY P WALCOTT
• 金额: $ 14.7万
• 依托单位: LIFEWAVE, INC.
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2009-05-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7273954
• 关键词: Affect; Algorithms; Anesthetics; Animal Model; Animals; Applications Grants; Arrhythmia; Artificial Heart; Blood Pressure; Bradycardia; Cardiac; Cardiopulmonary Resuscitation; Caregivers; Caring; Cause of Death; Characteristics; Chest; Clothing; Computer Systems Development; Data; Detection; Development; Devices; Educational process of instructing; Electrocardiogram; Family suidae; Guidelines; Hand; Health Personnel; Heart; Heart Arrest; Heart Rate; Hospitals; Human; Invasive; Laboratory Animals; Location; Logistic Regressions; Measures; Mechanics; Medical; Medical Device; Monitor; Motion; Organ; Output; Palpable; Patients; Performance; Phase; Physiologic pulse; Positioning Attribute; Pulse taking; Radar; Range; Rate; Receiver Operator Characteristics; Resuscitation; Right ventricular structure; Sense Organs; Signal Transduction; Specificity; Sternum; Stroke Volume; System; Tachycardia; Techniques; Testing; Time; Trauma; United States; Ventricular Fibrillation; atrioventricular node; base; computerized data processing; cost; fetal; heart motion; improved; mortality; prototype; receptor; sensor; software development

DESCRIPTION (provided by applicant): Cardiac arrest is a leading cause of death in the United States. Despite 40 years of teaching resuscitation techniques and pre-hospital system development to provide pre-hospital medical care rapidly, mortality remains high. It has recently been recognized that not performing chest compressions for relatively short periods of time during resuscitation may be responsible for a significant percentage of the high mortality. Resuscitation guidelines call for the stopping of chest compressions for the determination of the presence or absence of a carotid pulse by healthcare personnel when performing cardiopulmonary resuscitation, yet performance of pulse checks is time consuming and the results are often incorrect. LifeWave has developed an ultra-wideband radar sensor capable of detecting cardiac motion. We propose to develop the software algorithms that will allow this device to quickly determine whether or not a patient's cardiac motion is consistent with a palpable carotid pulse. This Phase 1 grant application has 2 specific aims: 1) Develop an algorithm that uses LifeWave's ultra-wideband radar signal to differentiate between the presence and absence of mechanical heart motion equivalent to the presence or absence of a palpable carotid pulse. We will use the radar sensor to record from animals with a range of heart rates and levels of cardiac contractility. We will use signal processing and statistical techniques to develop an algorithm that identifies whether or not the amount of cardiac motion present is consistent with the presence of a palpable carotid pulse (systolic blood pressure > 60 mmHg). We hypothesize that we will be able to differentiate between the presence and absence of a carotid pulse with 95% sensitivity and 70% specificity from 5 seconds of recorded data. 2) Show that the combination of the LifeWave medical radar and the signal processing algorithm developed in specific aim 1 can determine the mechanical heart motion associated with the presence or absence of a palpable carotid pulse during resuscitation of an animal model of sudden cardiac arrest. We hypothesize that by using the algorithm developed in specific aim 1, we will be able to differentiate between the presence and absence of a palpable carotid pulse with 95% sensitivity and 70% specificity from 5 seconds of data recording. Accomplishment of these two specific aims will show the ability of our ultra-wideband radar device to detect cardiac motion during resuscitation from cardiac arrest and prepare us for a phase II application and the development of a stand-alone radar monitor. Cardiac arrest is a leading cause of death in the United States. Despite 40 years of teaching resuscitation techniques and pre-hospital system development to provide pre-hospital medical care rapidly, mortality remains high. We propose to develop a radar-based pulse detection device that will decrease the amount of time spent performing pulse checks during resuscitation and not spent performing chest compressions. We hope that this device will improve survival following cardiac arrest.

描述（由申请人提供）：心脏骤停是美国的主要死因。尽管40年来一直在教授复苏技术和院前系统发展，以迅速提供院前医疗护理，但死亡率仍然很高。最近已经认识到，在复苏期间相对短的时间内不进行胸部按压可能是造成高死亡率的显著原因。复苏指南要求医护人员在进行心肺复苏时停止胸外按压以确定颈动脉脉搏的存在或不存在，但是脉搏检查的执行是耗时的并且结果通常是不正确的。LifeWave开发了一种能够检测心脏运动的超宽带雷达传感器。我们建议开发软件算法，使该设备能够快速确定患者的心脏运动是否与可触及的颈动脉脉搏一致。该第一阶段拨款申请有两个具体目标：1）开发一种算法，该算法使用LifeWave的超宽带雷达信号来区分机械心脏运动的存在和不存在，相当于存在或不存在可触及的颈动脉脉搏。我们将使用雷达传感器记录动物的心率和心脏收缩力水平。我们将使用信号处理和统计技术来开发一种算法，该算法可以识别存在的心脏运动量是否与可触及的颈动脉脉搏（收缩压> 60 mmHg）的存在一致。我们假设，我们将能够区分颈动脉搏动的存在和不存在，从5秒的记录数据中具有95%的灵敏度和70%的特异性。2)证明LifeWave医用雷达和特定目标1中开发的信号处理算法的组合可以确定与心脏骤停动物模型复苏期间存在或不存在可触及颈动脉脉搏相关的机械心脏运动。我们假设，通过使用特定目标1中开发的算法，我们将能够从5秒的数据记录中区分可触及颈动脉脉搏的存在和不存在，灵敏度为95%，特异性为70%。这两个具体目标的实现将显示我们的超宽带雷达设备在心脏骤停复苏过程中检测心脏运动的能力，并为第二阶段应用和独立雷达监测器的开发做好准备。在美国，心脏骤停是导致死亡的主要原因。尽管40年来一直在教授复苏技术和院前系统发展，以迅速提供院前医疗护理，但死亡率仍然很高。我们建议开发一种基于雷达的脉搏检测设备，该设备将减少在复苏期间执行脉搏检查所花费的时间，而不是执行胸外按压。我们希望这个装置能提高心脏骤停后的存活率。