Cancer Genetics Career Development Program

描述（由申请人提供）：这是一个既定的癌症遗传学职业发展计划（CGCDP）的竞争性更新申请，其目标是产生癌症遗传学和癌症预防研究的项目负责人。我们需要更多的领导者，有针对性的跨学科培训，推动癌症遗传学研究领域向前发展。需要对具有不同背景的研究人员进行交叉培训，以利用基因组学、蛋白质组学、遗传流行病学、癌症遗传学和分子医学的知识，将其转化为癌症预防。CGCDP是NCI R25 T产品组合中唯一的同类项目。在最初的项目期间，我们实现了最初资助的R25 T提案中概述的所有目标。我们开发了基础设施、专业课程、有效的咨询委员会，我们制定了招聘战略，并确定和接触了候选人申请库。我们招募了12名高素质的实习生（4名医学博士，2名博士护士，2名注册护士，4名遗传咨询师）-3/6的博士实习生是代表性不足的少数民族。招募工作包括在专业肿瘤学和遗传学期刊上刊登广告，网上列表，以及在全国会议上发布的引人注目的计划公告，并分发给145个医学肿瘤学和60个遗传学项目的负责人。为每位学员量身定制的教育计划提供4小时的课程，4小时的体验式培训，5小时的跨学科临床会议工作，每周至少26小时的研究经验/培训。专业课程包括一门新的临床癌症遗传学研究生课程，该课程是在第一个项目期间创建和试点的，并被批准为区域大学课程的永久地位。学员学习设计和实施高度跨学科的合作癌症遗传学和预防研究项目。个人教育计划强调跨学科的课程和会议，并专注于癌症研究项目的成熟和PHS 398赠款提案的准备。学员可同时攻读硕士学位和高级课程。在第一个供资期，受训人员的学术生产力非常出色，发表了8篇经同行评审的出版物。每个受训者在专业会议上提交一份或多份摘要。六份实习生补助金申请导致了校外资助。CGCDP校友继续在研究的职业轨迹（8 9校友已经采取了学术和/或研究职位，一个是参与行业教育），我们正在改进专业课程，引入新的癌症遗传学为重点的研讨会和讲座，增加新的研究和跨学科的培训元素，并增加经验丰富，资金充足的研究导师名册。有一个新的客座教授系列，以介绍癌症遗传学研究的思想领袖和潜在的职业轨迹，以及生物科学和生物信息学的新学术学位选择。CGCDP的成功体现在学员的生产力和安置上，并且对具有癌症遗传学新兴学科研究专长的医疗保健专业人员的持续迫切需求。我们的新重点，专门针对先前审查推荐的博士后学员，简化了该计划，并将资源集中在最有可能成为癌症遗传学独立研究科学家的学员身上。该计划的毕业生将通过将癌症遗传流行病学转化为个人风险评估工具和可接受的干预措施来减轻高风险人群的癌症负担。

DESCRIPTION (provided by applicant): This is a competitive renewal application for an established cancer genetics career development program (CGCDP), the goal of which is to generate program leaders for cancer genetics and cancer prevention research. We need more leaders with focused interdisciplinary training to move the field of cancer genetics research forward. Cross training of researchers with different backgrounds is needed to leverage knowledge of genomics, proteomics, genetic epidemiology, cancer genetics and molecular medicine for translation to cancer prevention. The CGCDP is the only program of its kind in the NCI R25T portfolio. In the initial project period we achieved all of the objectives outlined in the original funded R25T proposal. We developed the infrastructure, a specialized curriculum, an effective advisory committee, and we established recruitment strategies and identified and reached the candidate applicant pool. We recruited twelve highly qualified trainees (4 MDs, 2 PhD nurses, 2 RNs, 4 genetic counselors)-3/6 doctoral trainees are under-represented minorities. Recruitment efforts included advertising in professional oncology and genetics journals, web listings, and a compelling program announcement posted at national meetings and disseminated to directors of 145 medical oncology and 60 genetics programs. A tailored education plan for each trainee provides 4 contact hrs coursework, 4 hrs experiential training, 5 hrs interdisciplinary clinical conference work, and a minimum of 26 hrs research experience/training every week. The specialized curriculum includes a new graduate course in clinical cancer genetics that was created and piloted in the first project period, and approved for permanent status on the curriculum at a regional university. Trainees learn to design and implement highly interdisciplinary collaborative cancer genetics and prevention research projects. Individual education plans emphasize interdisciplinary coursework and conferences, and focus on maturation of cancer research projects and preparation of a PHS 398 grant proposal. Trainees may concurrently pursue a master's degree with advanced course work. In the first funding period, trainee academic productivity was exceptional and resulted in 8 peer-reviewed publications. Every trainee presented one or more abstracts at professional meetings. Six trainee grant applications have resulted in extramural funding. CGCDP alumni are continuing on research career trajectories (8 of 9 alumni have taken academic and/or research positions, and one is involved in industry education), We are improving the specialized curriculum, introducing new cancer genetics-focused workshops and lectures, adding new research and cross-disciplinary training elements, and growing the roster of experienced, well-funded research mentors. There is a new visiting professors series to profile thought leaders and potential career trajectories in cancer genetics research, and new academic degree options in biological sciences and bioinformatics. The success of the CGCDP is reflected by trainee productivity and placement, and there is a continued critical need for health care professionals with research expertise in the emerging discipline of cancer genetics. Our new emphasis, exclusively on post-doctoral trainees recommended by the previous review, streamlines the program and concentrates resources on trainees most likely to become independent research scientists in cancer genetics. The graduates of this program will reduce the burden of cancer among those at highest risk by translating cancer genetic epidemiology to individual risk assessment tools and acceptable interventions.