IFN-lambda signal transduction

我们的研究表明，IFN-λ维持信号转导和转录激活因子：STAT 1和STAT 2的激活超过8小时。这与这些转录因子在被I型IFN激活时的激活谱有显著差异。有趣的是，I型和III型IFN之间的基因活化动力学是不相同的。相反，I型IFN诱导基因转录更早，而IFN-λ介导的基因转录不仅延迟，而且持续更长时间。此外，IFN-λ在诱导对肿瘤细胞的抗增殖作用方面优于IFN-α。这些发现突出了IFN-λ在癌症治疗中的潜在治疗用途。我们的目标是测试这种细胞因子在小鼠肿瘤模型中的抗肿瘤和抗转移作用。

Our studies show that IFN-lambda sustains the activation of the signal transducers and activators of transcription: STAT1 and STAT2 for longer than 8 hours. This is a striking difference from the activation profile of these transcription factors when activated by type I IFNs. Interestingly the kinetics of gene activation between type I and type III IFNs are not the same. Rather, type I IFNs induce gene transcription earlier while IFN-lambda mediated gene transcription is not only delayed but sustained longer. In addition, IFN-lambda is better than IFN-alpha in inducing an antiproliferative effect on tumor cells. These findings highlight the potential therapeutic use of IFN-lambda in the treatment of cancer. Our goal is to test the antitumor and antimetastatic effects of this cytokine in mouse tumor models.