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Role chemoattractant receptors in inflammatory aspects o

Role chemoattractant receptors in inflammatory aspects o
趋化受体在炎症方面的作用
批准号:
7338803
负责人:
JI MING WANG
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
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英文摘要
We have found that the receptor FPRL1 recognizes Alzheimer's disease-associated amyloid beta peptides and promotes proinflammatory responses in the brain. We used mouse FPRL1 counterpart mFPR2 as a model for further understanding of the receptor in the progression of the disease. We found that mFPR2 in microglial cells, the macrophages in the brain, is upregulated by diverse proinflammatory stimulants, including agonists for the pattern recognition receptors and cytokines. Increased expression of mFPR2 on microglial cells enhances the capacity of the cells to endocytose amyloid beta peptide, therefore the receptor may profoundly affect the progression of the disease.
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IDENTIFICATION OF CELLULAR RECEPTORS INVOLVED IN HIV INFECTION, TUMOR METASTASIS
Cellular Receptors in HIV Infection/Acute Phase Response
Identification of Cellular Receptors Involved in HIV Infection, Tumor Metastasis
The Role of Cellular Receptors Involved in Inflammation and Tumor Progression
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海外基金
CCL8介导ALA光动力治疗皮肤鳞状细胞癌的效应与机制研究
  • 批准号:
    81602396
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    18.0万元
  • 批准年份:
    2016
  • 负责人:
    吉杰
  • 依托单位:
小胶质细胞的IL-6/JAK/STAT3/MCP-1信号途径在MS/EAE发病过程中的作用
  • 批准号:
    81070958
  • 项目类别:
    面上项目
  • 资助金额:
    32.0万元
  • 批准年份:
    2010
  • 负责人:
    程琦
  • 依托单位: