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Chemotactic Formylpeptide Receptor DevelopmentProgression Malignant Human Gliom

Chemotactic Formylpeptide Receptor DevelopmentProgression Malignant Human Gliom
趋化甲酰肽受体的发育进展人类恶性胶质瘤
批准号：
7592882
负责人：
JI MING WANG
金额：
$27.05万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7592882
关键词：
AgonistCell CommunicationCell Differentiation processCellsChemotaxisCoupledEnvironmentG-Protein-Coupled ReceptorsGlioblastomaGliomaHumanMalignant - descriptorMolecularNecrosisNude MiceProductionRNA InterferenceRegulationRoleSignal TransductionSignal Transduction PathwaySmall Interfering RNASpecimenTumorigenicityVascular Endothelial Growth FactorsXenograft Modelknock-downmalignant phenotypeneoplastic cellreceptorselective expressionsensortumortumor progressiontumorigenesis

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英文摘要
We have found that a G-protein coupled receptor FPR is selectively expressed by highly malignant human glioblastoma cells. Activation of FPR promotes tumor cell chemotaxis, survival and production of angiogenic facotr VEGF. Knocking down FPR by small interfering RNA markedly reduces the capacity of glioblastoma cells to form tumors in nude mice. In addition, FPR is activated by agonist activity contained in the supernatants of necrotic tumor cells. Thus, FPR acts as a sensor on glioblastoma cells for agonists produced in the tumor environment to exacerbate the progression of the tumor.
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