PRECLINICAL THERAPEUTICS

临床前治疗

• 批准号: 7506568
• 负责人: ROSEMARY J AKHURST
• 金额: $ 13.78万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-25 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7506568
• 关键词: Animal Model; Animals; Antineoplastic Agents; Cancer Model; Cancer cell line; Cells; Characteristics; Collaborations; Comprehensive Cancer Center; Consultations; Core Facility; Data; Databases; Ensure; Experimental Designs; Fostering; Generations; Genetically Engineered Mouse; Growth; Guidelines; Housing; Human; Human Resources; Image; Imaging technology; Malignant Neoplasms; Modeling; Monitor; Mus; Numbers; Operative Surgical Procedures; Reproducibility; Research; Research Personnel; Resources; Services; Techniques; Testing; Therapeutic; Training; Tumor Burden; Xenograft procedure; animal resource; base; cell growth; human cancer mouse model; in vivo; interest; neoplastic cell; novel diagnostics; oncology; pre-clinical; preclinical study; response; tumor

The Preclinical Therapeutics Core (PCTC) facility generates tumor-bearing animals and conducts preclinical oncology trials for UCSF Comprehensive Cancer Center investigators. Offering a variety of xenograft-based cancer models, the core provides services that include consultation regarding experimental design, tumor cell growth in culture and generation of tumors in mice, administration of experimental agents, monitoring of tumor burden and response to therapy, and interpretation of study results. The PCTC maintains a cryorepository of commonly used human cancer cell lines derived from multiple tumor types along with data regarding their in vivo growth characteristics, and a user-accessible data base of genetically-engineered mouse models of human cancer maintained within the UCSF CCC, in order to foster collaboration between labs actively utilizing these models, and investigators interested in undertaking pre-clinical trials thereon. The PCTC is also a resource of expertise in small animal survival surgery, and is available to provide training in these techniques on a recharge basis. Although the core primarily functions to test experimental anti-cancer agents in vivo, it also provides animal models of human cancer for use in novel diagnostic, tumor, imaging, and basic mechanistic research. The core oversees, maintains and provides as a service a number of small animal imaging technologies housed within the barrier facility. The availability of centralized cell and animal resources, together with personnel with expertise in conducting preclinical studies, ensures appropriate experimental design and reproducibility, compliance with local and federal regulatory guidelines for tumorbearing animals, and maximum resource utilization through coordinated animal purchasing and housing.

临床前治疗核心（PCTC）设施产生荷瘤动物，并进行临床前 UCSF综合癌症中心研究人员的肿瘤学试验。提供多种基于异种移植的 癌症模型，核心提供的服务，包括咨询有关实验设计，肿瘤 培养物中的细胞生长和小鼠中肿瘤的产生，实验试剂的施用， 肿瘤负荷和对治疗的反应，以及研究结果的解释。PCTC保持一个 来源于多种肿瘤类型的常用人癌细胞系的冷冻库，其中沿着数据 关于它们的体内生长特性，以及基因工程的用户可访问的数据库， 在UCSF CCC内维持的人类癌症小鼠模型，以促进 积极利用这些模型的实验室，以及对进行临床前试验感兴趣的研究人员。的 PCTC也是小动物生存手术的专业知识资源，并可提供以下培训： 这些技术在充电的基础上。虽然核心的主要功能是测试实验性抗癌药物 本发明还提供了用于新的诊断、肿瘤、成像 和基本的机械研究。核心监督、维护和提供一些小型的 隔离设施内的动物成像技术。集中式细胞和动物的可用性 资源，以及在进行临床前研究方面具有专业知识的人员， 实验设计和重现性，符合当地和联邦的荷瘤监管指南 动物，并通过协调动物购买和住房最大限度地利用资源。