ENVIRONMENTAL INFLUENCES ON THE PERINATAL LUNG DEVELOPMENT

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。目的：1.研究猴在发育的关键时期(从妊娠早期到出生后13个月)暴露于一种常见室内空气污染物(ETS)的情况，以及与超声检查、羊水和母婴血液样本的相关性。2.用形态学、生理学、生物化学和免疫生物学方法研究ETS对围生期发育关键时期(从早期妊娠到出生后13个月龄)猴肺的影响。3.为了确定同样的围产期ETS暴露是否增加了肺中神经营养素的产生，并与C纤维中P物质的产生增加导致CNS呼吸反应夸大有关。4.确定围产期后停止接触ETS是否会改善效果，或与肺部及其神经控制的持续变化有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objectives: 1. To characterize conditions of exposure to a common indoor air pollutant (ETS) in monkeys during critical windows of development (ranging from early gestation to 13 months postnatal age) correlated to measures from ultrasonography, amniotic fluid and blood samples of the mother and/or infant. 2. To determine the consequences in the lung of exposure to ETS in monkeys during critical perinatal periods of development (from early gestation to 13 months postnatal age) using morphological, physiologic, biochemical and immunobiological approaches to measure effects. 3. To determine if the same perinatal ETS exposure enhances neurotrophin production in the lungs in association with increased production of substance P in C-fibers resulting in exaggerated CNS respiratory responses. 4. To determine if cessation of exposure to ETS after the perinatal period will ameliorate effects or be associated with persistent changes in the lung and its neural control.