Engineered Nanomaterials: Linking Physical and Chemical Properties to Biology

工程纳米材料:将物理和化学特性与生物学联系起来

基本信息

  • 批准号:
    8462273
  • 负责人:
  • 金额:
    $ 48.29万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-09-27 至 2015-04-30
  • 项目状态:
    已结题

项目摘要

The goal of this program is to systematically explore the influence of physicochemical properties of size, composition, surface lability as well as charge, density, and activity of engineered nanomaterials (ENMs). The goal of this project is to define the effect of these physical/chemical properties on how ENMs interact with the intact organism, including specific target organs and specific cell types within the target organs. We will focus one ofthe major classes of ENMs, the high aspect ratio nanomaterials (HARNMs), including single wall carbon nanotubes (SWNTs) and nanowires (NWs) of various lengths. The importance of size (diameter and length) and coatings (silica as one example) to affect toxicity, retention and translocation will be assessed. HARNM with differing physical/chemical property described above will be employed in a series of systematic examinations of absorption and distribution following inhalation/ingestion experiments. Primary and secondary target organ responses will be monitored, and the influence of HARNM exposure In a model of allergy will be assessed. The overall hypothesis Is that differences in composition, size, diameter and surface coating of HARNMs will modulate the in vivo uptake, distribution and biologic effects of HARNMs in a rat model. This hypothesis will be addressed in four specific aims that will determine the effect of HARNM on 1) deposition, retention and distribution to various organs; 2) respiratory system cytotoxicity, inflammation and airway remodeling; 3) oxidative stress in the respiratory system; and 4) exacerbation of ainway hyperresposiveness in a sensitive model. We will address these aims using a transdisciplinary approach that combines inhalation toxicology, chemistry, histopathology, high resolution imaging and novel methodologies developed at UC Davis that uniquely position us to successfully address the biological effects of these materials. The long term goal is to identify features of these materials that reduce their toxicity and biological effects. RELEVANCE (See instnjctions); To develop and evaluate techniques and approaches to assess the potential disease burden associated with exposures to ENMs. The goal of Project 2 is to define exposure effects of high aspect ratio nanomaterials (single walled carbon nanotubes and nanowires) in an in vivo inhalation model that includes airways hyperresonsiveness.
这个项目的目标是系统地探索尺寸的物理化学性质的影响,

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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KENT Ed PINKERTON其他文献

KENT Ed PINKERTON的其他文献

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{{ truncateString('KENT Ed PINKERTON', 18)}}的其他基金

Western Center for Agricultural Health and Safety
西部农业健康与安全中心
  • 批准号:
    10909766
  • 财政年份:
    2022
  • 资助金额:
    $ 48.29万
  • 项目类别:
Western Center for Agricultural Health and Safety
西部农业健康与安全中心
  • 批准号:
    10557448
  • 财政年份:
    2022
  • 资助金额:
    $ 48.29万
  • 项目类别:
Effects of e-cigarette exposure during pregnancy on offspring lung function and disease: Characterization of pulmonary, intergenerational, and epigenetic effects
怀孕期间接触电子烟对后代肺功能和疾病的影响:肺、代际和表观遗传效应的特征
  • 批准号:
    10167106
  • 财政年份:
    2018
  • 资助金额:
    $ 48.29万
  • 项目类别:
Effects of e-cigarette exposure during pregnancy on offspring lung function and disease: Characterization of pulmonary, intergenerational, and epigenetic effects
怀孕期间接触电子烟对后代肺功能和疾病的影响:肺、代际和表观遗传效应的特征
  • 批准号:
    10249200
  • 财政年份:
    2018
  • 资助金额:
    $ 48.29万
  • 项目类别:
The Western Center for Agricultural Health and Safety-Renewal
西部农业健康与安全中心更新
  • 批准号:
    9197388
  • 财政年份:
    2016
  • 资助金额:
    $ 48.29万
  • 项目类别:
The Western Center for Agricultural Health and Safety
西部农业健康与安全中心
  • 批准号:
    10438137
  • 财政年份:
    2016
  • 资助金额:
    $ 48.29万
  • 项目类别:
Agriculture and Climate Change Impacts on Workers' Health and Safety
农业和气候变化对工人健康和安全的影响
  • 批准号:
    9341203
  • 财政年份:
    2016
  • 资助金额:
    $ 48.29万
  • 项目类别:
Respiratory and Ocular Toxicity of Inhaled Nanomaterials
吸入纳米材料的呼吸和眼毒性
  • 批准号:
    9770859
  • 财政年份:
    2016
  • 资助金额:
    $ 48.29万
  • 项目类别:
Engineered Nanomaterials: Linking Physical and Chemical Properties to Biology
工程纳米材料:将物理和化学特性与生物学联系起来
  • 批准号:
    8282907
  • 财政年份:
    2010
  • 资助金额:
    $ 48.29万
  • 项目类别:
Engineered Nanomaterials: Linking Physical and Chemical Properties to Biology
工程纳米材料:将物理和化学特性与生物学联系起来
  • 批准号:
    8137404
  • 财政年份:
    2010
  • 资助金额:
    $ 48.29万
  • 项目类别:

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