H2A.Z acetylation: Deregulation of enhancer activity and 3D chromatin in prostate cancer

H2A.Z 乙酰化：前列腺癌中增强子活性和 3D 染色质的失调

• 批准号: nhmrc : 1144574
• 负责人: Dr Fatima Valdes Mora
• 金额: $ 58.1万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/h2az-acetylation-deregulation-prostate-cancer/1320223
• 关键词: H2A.Z; acetylation; Deregulation; enhancer; activity

DNA is not linear but packaged in the cell nucleus in a three-dimensional (3D) structure in such a way that distal regulatory regions can interact to control gene expression. Our new data suggests that a chemical modification of the histone variant H2A.Z plays a critical role in the formation of the 3D chromatin structure. This project is aimed to dissect the role of H2A.Z in prescribing 3D structure, which will provide a more precise understanding of gene deregulation in cancer.

DNA不是线性的，而是以三维(3D)结构包装在细胞核中，这样末端调节区可以相互作用来控制基因的表达。我们的新数据表明，组蛋白变异体H2A.Z的化学修饰在3D染色质结构的形成中起着关键作用。这个项目的目的是剖析H2A.Z在规定3D结构中的作用，这将为更准确地理解癌症中的基因去调控提供帮助。