Importance of Histone Variant H2AZ Acetylation in Gene Activation in Cancer

组蛋白变异体 H2AZ 乙酰化在癌症基因激活中的重要性

• 批准号: nhmrc : 1063560
• 负责人: Dr Fatima Valdes Mora
• 金额: $ 40.79万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/importance-histone-variant-activation-cancer/455066
• 关键词: Importance; Histone; Variant; H2AZ; Acetylation

DNA is packaged in the cell in such a way that essential genes are available to be switched on by the transcription machinery. The packaging involves nucleosomes, that consist of four histone proteins, H2A, H2B, H3 and H4. H2A.Z is a histone variant that is often over expressed in cancer, and therefore could lead to abnormal gene transcription. This project is focused on understanding the role of H2A.Z in gene deregulation in cancer as modification of this mark may provide a potential novel cancer therapeutic target.

DNA在细胞中以这样一种方式包装，即必需基因可由转录机制启动。包装涉及核小体，由四种组蛋白H2A，H2B，H3和H4组成。H2A.Z是一种组蛋白变体，通常在癌症中过度表达，因此可能导致基因转录异常。该项目的重点是了解H2A.Z在癌症基因失调中的作用，因为该标记的修饰可能提供潜在的新型癌症治疗靶点。