MENOPAUSAL HOT FLASHES

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。建立绝经期潮热的灵长类动物模型。在美国，有3000多万女性患有更年期潮热，这与严重的不适、失眠、疲劳和可能的抑郁症有关。虽然激素替代疗法是治疗潮热的有效方法，但大多数女性由于害怕癌症而没有接受这种疗法。更好地了解潮热的原因将有助于改进治疗方法的发展。我们已经证明，潮热是由体温的微小波动引发的，作用于调节过于严格的恒温器。由于恒温器(下丘脑)位于大脑的中央，在人类身上很难研究它。我们正在研究是否可以在更年期的恒河猴模型上复制人类潮热的指标，如皮肤温度升高和出汗。这项研究使用了WNPRC动物服务和老龄资源。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To develop a primate model of menopausal hot flashes. More than 30 million women in the U.S. suffer from menopausal hot flashes, which are associated with severe discomfort, sleep loss, fatigue and, possibly, depression. Although hormone replacement therapy is an effective treatment for hot flashes, most women do not receive it due to a fear of cancer. A better understanding of the causes of hot flashes will aid in the development of improved treatments. We have shown that hot flashes are triggered by small fluctuations in body temperature acting on a thermostat that is too tightly regulated. Since the thermostat (hypothalamus) is located in the middle of the brain, it is not easily studied in humans. We are studying whether we can replicate human indicators of hot flashes, such as increased skin temperature and sweating, in rhesus monkey models of menopause. This research used WNPRC Animal Services and Aging Resources.