STATISTICAL GENETICS AND TREATMENT ANALYSIS

统计遗传学和治疗分析

• 批准号: 8120342
• 负责人: ROBERT R FREEDMAN
• 金额: $ 9.52万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8120342
• 关键词: Accounting; Admixture; Affect; Alleles; Antipsychotic Agents; Area; Biometry; Brain; Candidate Disease Gene; Clinical Research; Clinical Trials; Collaborations; Collection; Colorado; Commit; Communication; Complex; Consult; Data; Data Analyses; Development; Doctor of Philosophy; Ensure; Epidemiology; Faculty; Family; Frequencies; Gene Expression; Gene Frequency; Genes; Genetic; Genetic Polymorphism; Genetic Variation; Genome; Genotype; Haplotypes; Heterogeneity; Human; Human Resources; Impaired cognition; Individual; Infant Development; Instruction; Insulin Resistance; Intervention; Joints; Linear Regressions; Logistic Regressions; Measurement; Methodology; Methods; Modeling; Molecular Genetics; Mus; NRG1 gene; Nature; Neuregulins; Nicotine; Nicotinic Receptors; Outcome; Paper; Persons; Pharmaceutical Preparations; Phase II Clinical Trials; Phenotype; Plasma; Predisposition; Preparation; Principal Investigator; Psychotic Disorders; Recording of previous events; Regulation; Reporting; Research Design; Research Personnel; Sampling; Schizophrenia; Series; Services; Statistical Methods; Students; Subjects Selections; Symptoms; TNFRSF5 gene; Techniques; Testing; Therapy Clinical Trials; Time; Universities; Variant; Vertebrates; Weight; Work; base; case control; comparison group; design; experience; follow-up; gene interaction; genetic association; genetic epidemiology; genetic variant; graduate student; human subject; improved; interest; member; new therapeutic target; novel therapeutics; prevent; proband; professor; programs; promoter; research study; sensory gating; statistics; tool; trait

The Statistical Genetics and Treatment Analysis Core is designed to provide support in study design, data analysis, and interpretation. All Core members participate in preparation of reports, presentations, and manuscnpts. In addition. Core members will continue their efforts to develop new statistical approaches that will improve the analytic techniques available to Center investigators. Specific developments include methods to increase the power for association analysis in an area with a known linkage and methods to assign a false discovery rate to multiple gene expression measurements in a microarray experiment. Core B provides services to all five Projects. RELEVANCE (See instructions): New therapeutic strategies for schizophrenia are needed to improve cognitive dysfunction and negative symptoms and to prevent the development of psychosis. The Center investigates a nicotinic acetylcholine receptor as a new therapeutic target. Investigational results are used to design a new drug treatment for schizophrenia and a preventative nutnent intervention dunng infant development, both of which activate this rpr.pntr>r

统计遗传学和治疗分析核心旨在为研究设计、数据提供支持 分析和解释。所有核心成员都参与准备报告、演示文稿和 手稿。此外。核心成员将继续努力制定新的统计方法，以 将改进中心调查人员可用的分析技术。具体发展情况包括 在已知关联的区域中增加关联分析能力的方法和方法 在微阵列实验中，将错误发现率分配给多个基因表达测量。 核心B为所有五个项目提供服务。 相关性(请参阅说明)： 精神分裂症需要新的治疗策略来改善认知功能障碍和负性 并能预防精神病的发展。该中心研究一种烟碱型乙酰胆碱 受体作为新的治疗靶点。研究结果被用来设计一种新的药物治疗方法 精神分裂症和预防性坚果干预阻碍婴儿发育，两者都激活了这一点 Rpr.pntr&gt；r