BABOON MODEL FOR GENETICS OF HUMAN GENERALIZED EPILEPSY

人类全身性癫痫遗传学的狒狒模型

• 批准号: 7349833
• 负责人: Jeff Williams
• 金额: $ 5.01万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349833
• 关键词: BABOON; MODEL; GENETICS; HUMAN; GENERALIZED

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The red baboon (Papio hamadryas papio) was first explored more than thirty years ago as a nonhuman primate model of primary generalized epilepsy in humans, and remains one of the best characterized electroclinical animal models for juvenile myoclonic epilepsy. Epilepsy is easily studied in the baboon because these animals are highly susceptible to photic stimulation to provoke neuronal discharges and seizures that are sensitive markers of their epileptic syndrome. The goal of this project is to develop additional species of baboon (P.h. anubis [olive baboon], P.h. cynocephalus [yellow baboon], and their hybrids) as a nonhuman primate model for the genetics of primary generalized epilepsy in humans. Using the large, genotyped baboon pedigree at Southwest Foundation for Biomedical Research (SFBR) San Antonio, TX, we will seek genes that significantly affect variation in the clinical and electroencephalographic features of epilepsy in baboons and are therefore likely to be relevant in human epilepsy. Identification of genes involved in the epilepsy syndrome will implicate specific physiological and biochemical pathways that can be targeted for intervention, and potentially contribute to improvements in existing treatments for epilepsy and the development of novel therapies.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。红狒狒（Papio hamadryas Papio）是三十多年前首次作为人类原发性广泛性癫痫的非人类灵长类动物模型进行研究的，并且仍然是青少年肌阵挛性癫痫的最佳电临床动物模型之一。在狒狒身上很容易研究癫痫，因为这些动物对光刺激非常敏感，从而引起神经元放电和癫痫发作，这是它们癫痫综合征的敏感标志。该项目的目标是开发其他种类的狒狒（P.h. anubis[橄榄狒狒]，P.h. cynocephalus[黄狒狒]及其杂交品种），作为人类原发性全身性癫痫遗传学的非人类灵长类动物模型。利用德克萨斯州圣安东尼奥西南生物医学研究基金会（SFBR）的大型基因分型狒狒系谱，我们将寻找显著影响狒狒癫痫临床和脑电图特征变异的基因，因此可能与人类癫痫有关。确定与癫痫综合征相关的基因将涉及特定的生理和生化途径，这些途径可以作为干预的目标，并可能有助于改进现有的癫痫治疗方法和开发新疗法。