NONHUMAN PRIMATE MODEL OF MYCOPLASMA PNEUMONIAE PNEUMONIA

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this project is to establish a non-human primate model of Mycoplasma pneumoniae pneumonia. The first step is to administer pure toxin to the lung of a cull baboon (a second cull will receive the carrier plus heat inactivated toxin and serve as the control). We will characterize the inflammatory response mechanism by defining the role of cytokines known to be markers of inflammation in bronchoalveolar lavage (BAL), their influence on histopathologic lesions, and the distribution of toxin in selected tissues. If the toxin elicits a marked cytokine response compared to the control (heat inactivated toxin) we will apply to administer live organism to additional baboons.