Influence of mechanical force application on human mesenchymal stem cell differentiation

机械力施加对人间充质干细胞分化的影响

• 批准号: BB/D000548/1
• 负责人: Sarah Cartmell
• 金额: $ 34.38万
• 依托单位: Keele University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FD000548%2F1
• 关键词: Influence; mechanical; force; application; human

A type of cell called a mesenchymal stem cell exists in human bone marrow. These special cells have the capability to grow into many different types of other cells such as bone cells, cartilage cells and muscle cells. In order to do this, these cells need certain types of stimuli. One of these types of stimuli is mechanical force. Very little is known about how mechanical forces affect mesenchymal stem cells. This project aims to analyse in detail, the effects of three different types of mechanical force on these cells over time periods of ten minutes to two weeks. Different types of mechanical forces (such as fluid flowing over a cell or stretching a cell by growing it on a plastic membrane and then pulling the membrane) causes the cell to react and adapt differently to their environment. This project will identify how these cells react to each type and length of force application and ultimately what type of cell it will then be destined to grow into as a result of the force.

人类骨髓中存在一种称为间充质干细胞的细胞。这些特殊细胞能够生长成许多不同类型的其他细胞，例如骨细胞、软骨细胞和肌肉细胞。为了做到这一点，这些细胞需要某些类型的刺激。这些类型的刺激之一是机械力。人们对机械力如何影响间充质干细胞知之甚少。该项目旨在详细分析三种不同类型的机械力在十分钟到两周的时间内对这些细胞的影响。不同类型的机械力（例如流体流过细胞或通过在塑料膜上生长细胞然后拉动膜来拉伸细胞）导致细胞对其环境做出不同的反应和适应。该项目将确定这些细胞如何对每种类型和长度的力施加做出反应，以及最终由于力的作用而注定会生长成什么类型​​的细胞。