Novel tendon attachment and repair strategy

新颖的肌腱附着和修复策略

• 批准号: MR/M007642/1
• 负责人: Sarah Cartmell
• 金额: $ 155.61万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FM007642%2F1
• 关键词: Novel; tendon; attachment; repair; strategy

Every year there are >3,000people that injure their hand tendons. Currently, only 60% of these people result with an effective repair. This is because scar tissue forms that is not the same as its original tissue, making the hand stiff and difficult to move properly. This poor healing not only has an impact on the person with the injury, but also on the NHS as physiotherapy and occupational therapy costs post injury as a result are high. This project proposes an exciting and novel approach to repairing tendons. It allows mechanical loads to be transferred across the healing tendon which will promote new healthy tissue repair and reduce the formation of scars. We have a currently funded DPFS grant that has given us a promising set of data that demonstrates how state of the art polymer nano-fibres can be used in tendon repair. This data is in small rodents only and we now seek further MRC DPFS funding to perform larger animal model studies to translate this product development to the clinic. The proposed multidisiplinary research team have international track records in the area of clinical tendon repair, biomaterials development and medicinal product translation. In this project, this team will gather the regulatory data necessary on this novel medical device read for clinical trial following this project.

每年有30万人手部肌腱受伤。目前，这些人中只有60%的人得到了有效的修复。这是因为疤痕组织的形成与原来的组织不一样，使手僵硬，难以正常移动。这种糟糕的愈合不仅对受伤的人有影响，而且对NHS也有影响，因为受伤后的物理治疗和职业治疗费用很高。这个项目提出了一种令人兴奋和新颖的修复肌腱的方法。它允许机械负荷通过愈合肌腱转移，这将促进新的健康组织修复并减少疤痕的形成。我们目前获得了DPFS的资助，这给了我们一组有希望的数据，展示了最先进的聚合物纳米纤维如何用于肌腱修复。这些数据仅在小型啮齿动物中，我们现在寻求进一步的MRC DPFS资助，以进行更大的动物模型研究，将该产品开发转化为临床。拟建的多学科研究团队在临床肌腱修复、生物材料开发和医药产品翻译领域具有国际跟踪记录。在这个项目中，这个团队将收集这种新型医疗设备的必要监管数据，以便在这个项目之后进行临床试验。

项目成果

Enhancing Biocompatibility without Compromising Material Properties: An Optimised NaOH Treatment for Electrospun Polycaprolactone Fibres

• DOI: 10.1155/2019/4605092
• 发表时间: 2019-01-01
• 期刊: JOURNAL OF NANOMATERIALS
• 作者: Bosworth, Lucy A.;Hu, Wanxiao;Cartmell, Sarah H.
• 通讯作者: Cartmell, Sarah H.

Improving Outcomes in Tendon Repair: A Critical Look at the Evidence for Flexor Tendon Repair and Rehabilitation

• DOI: 10.1097/prs.0000000000002769
• 发表时间: 2016-12-01
• 期刊: PLASTIC AND RECONSTRUCTIVE SURGERY
• 影响因子: 3.6
• 作者: Khor, Wee S.;Langer, Martin F.;Wong, Jason K. F.
• 通讯作者: Wong, Jason K. F.

Abrogation of TGF-beta signalling in TAGLN expressing cells recapitulates Pentalogy of Cantrell in the mouse.

• DOI: 10.1038/s41598-018-21948-z
• 发表时间: 2018-02-26
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Aldeiri B;Roostalu U;Albertini A;Behnsen J;Wong J;Morabito A;Cossu G
• 通讯作者: Cossu G

Sutured tendon repair; a multi-scale finite element model.

• DOI: 10.1007/s10237-014-0593-5
• 发表时间: 2015-01
• 期刊: BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
• 影响因子: 3.5
• 作者: Rawson, Shelley D.;Margetts, Lee;Wong, Jason K. F.;Cartmell, Sarah H.
• 通讯作者: Cartmell, Sarah H.

Sterilisation effects on electrospun fibres manufactured from different grades of poly(e-caprolactone)

不同等级聚己内酯制造的静电纺纤维的灭菌效果

• 发表时间: 2015
• 期刊: Journal of Materials Science Letters
• 作者: Ghag AK