Does Early Experience Improve Preterm Neurodevelopment?

早期经验能否改善早产神经发育?

基本信息

  • 批准号:
    7434365
  • 负责人:
  • 金额:
    $ 43.12万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2006
  • 资助国家:
    美国
  • 起止时间:
    2006-08-01 至 2011-05-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): About fifty percent of prematurely born infants develop learning/behavior problems and school failure. The study will test the primary hypotheses, that preterm infants (PT) randomized to developmental care in the Newborn Intensive Care Unit (NICU) will be superior in cognitive performance at school age when compared to their peers, who did not receive the intervention. Fifty-two [26 control (C); 26 experimental (E)] infants born at a gestational age (GA) of 28-33 week (w) will be studied at 8 years(y) corrected age (CA). A sample of 26 fullterm-born (FT) healthy 8y-olds will provide an additional control group for descriptive purposes. Three secondary hypotheses will be tested: The PT-E group will be superior to the PT-C, 1) in academic performance; 2) in long distance cortical connectivity of frontal and occipital brain systems (EEC coherence), and 3) in frontal cortical white matter volumes (MRI). The FT group will be superior to both PT groups. Child physical and psychosocial functioning will be explored descriptively. The primary independent variable will be treatment group (PT-control, PT-experimental). Additionally tested will be GA, growth percentile (weight and head circumference) at birth, parent socioeconomic status, and parent cognitive function, all expected to influence outcome. The PT sample will be described by previously collected medical and demographic measures at birth, and by behavior and brain function at 2wCA and 9mCA. For testing the primary (school age cognitive function) and the two secondary dependent variables (frontal coherence and frontal white matter volume), stepwise multiple linear regression analysis will be used; the five independent variables will be entered into the models. Main effects and two and three-way interaction terms will be evaluated with goodness-of-fit assessed using adjusted R-squared. A sample size of 26 subjects per PT group will provide 80% statistical power (beta=0.20; alpha=0.05, 2-tailed) to detect a 12 point or higher mean difference in the cognitive measure, assuming a pooled standard deviation of 15 points (effect size sigma = 12/15 = 0.8) based on a two-sample Student t-test. The study will provide, for the first time, evidence at school age of the effectiveness of a much needed, low cost, early behavioral intervention. The expected reduction in learning and school failure for the increasing numbers of preterm-born children in the nation's schools, would give the study and the intervention, significant national public health importance.,
描述(由申请人提供):大约50%的早产儿会出现学习/行为问题和学业失败。该研究将检验主要假设,即与未接受干预的同龄人相比,在新生儿重症监护室(NICU)随机接受发育护理的早产儿(PT)在学龄期的认知表现将优于上级。52名[26名对照组(C); 26名实验组(E)]胎龄(GA)为28-33周(w)的婴儿将在8岁(y)校正年龄(CA)时进行研究。26例足月出生(FT)健康8岁儿童的样本将提供额外的对照组,用于描述目的。将检验三个次要假设:PT-E组上级PT-C组,1)在学习成绩方面; 2)在额叶和枕叶脑系统的长距离皮质连接性(EEC相干性)方面; 3)在额叶皮质白色体积(MRI)方面。FT组上级两个PT组。儿童的生理和心理社会功能将被探索。主要自变量为治疗组(PT-对照,PT-实验)。此外,还将测试GA、出生时生长百分位数(体重和头围)、父母社会经济状况和父母认知功能,所有这些预期都会影响结局。PT样本将通过出生时先前收集的医学和人口统计学指标以及2 wCA和9 mCA时的行为和脑功能进行描述。对于主要(学龄认知功能)和两个次要因变量(额叶连贯性和额叶白色物质体积)的检验,将使用逐步多元线性回归分析;将五个自变量输入模型。将使用调整后的R平方评估拟合优度,评价主效应以及双向和三向相互作用项。每个PT组26例受试者的样本量将提供80%的统计把握度(β =0.20; α =0.05,双尾),以检测认知指标的平均差异为12分或更高,基于双样本Student t检验,假设合并标准差为15分(效应量σ = 12/15 = 0.8)。这项研究将首次提供学龄儿童的证据,证明急需的低成本早期行为干预的有效性。预计全国学校中越来越多的早产儿的学习和学业失败会减少,这将使这项研究和干预措施具有重要的国家公共卫生重要性。

项目成果

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{{ truncateString('HEIDELISE ALS', 18)}}的其他基金

Preterm Fetal Growth Restriction and Developmental Care
早产胎儿生长受限和发育护理
  • 批准号:
    7933162
  • 财政年份:
    2009
  • 资助金额:
    $ 43.12万
  • 项目类别:
PRETERM FETAL GROWTH
早产胎儿生长
  • 批准号:
    7719320
  • 财政年份:
    2008
  • 资助金额:
    $ 43.12万
  • 项目类别:
PRETERM FETAL GROWTH
早产胎儿生长
  • 批准号:
    7607379
  • 财政年份:
    2007
  • 资助金额:
    $ 43.12万
  • 项目类别:
Does Early Experience Improve Preterm Neurodevelopment?
早期经验能否改善早产神经发育?
  • 批准号:
    7847566
  • 财政年份:
    2006
  • 资助金额:
    $ 43.12万
  • 项目类别:
Does Early Experience Improve Preterm Neurodevelopment?
早期经验能否改善早产神经发育?
  • 批准号:
    7048138
  • 财政年份:
    2006
  • 资助金额:
    $ 43.12万
  • 项目类别:
Does Early Experience Improve Preterm Neurodevelopment?
早期经验能否改善早产神经发育?
  • 批准号:
    7264515
  • 财政年份:
    2006
  • 资助金额:
    $ 43.12万
  • 项目类别:
Does Early Experience Improve Preterm Neurodevelopment?
早期经验能否改善早产神经发育?
  • 批准号:
    7622688
  • 财政年份:
    2006
  • 资助金额:
    $ 43.12万
  • 项目类别:
PRETERM FETAL GROWTH RESTRICTION AND DEVELOPMENT CARE
早产胎儿生长受限和发育护理
  • 批准号:
    7379253
  • 财政年份:
    2006
  • 资助金额:
    $ 43.12万
  • 项目类别:
PRETERM FETAL GROWTH RESTRICTION AND DEVELOPMENT CARE
早产胎儿生长受限和发育护理
  • 批准号:
    7204533
  • 财政年份:
    2005
  • 资助金额:
    $ 43.12万
  • 项目类别:
Preterm Fetal Growth Restriction and Developmental Care
早产胎儿生长受限和发育护理
  • 批准号:
    6915736
  • 财政年份:
    2004
  • 资助金额:
    $ 43.12万
  • 项目类别:

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