EVALUATION OF IN SITU CROSSLINKABLE BIOMATERIAL FOR OSTEOCHONDRAL DEFECT REPA

用于骨软骨缺损修复的原位可交联生物材料的评估

• 批准号: 7358297
• 负责人: Lori A. Setton
• 金额: $ 0.51万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7358297
• 关键词: EVALUATION; SITU; CROSSLINKABLE; BIOMATERIAL; OSTEOCHONDRAL

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this work is to evaluate the ability of a bioelastic polymer to act as a scaffold and support articular cartilage repair in an osteochondral defect in a goat model. Goat knees undergo a bilateral procedure to create a large cartilage defect on the femoral condyle; one side is filled with a custom synthesized biopolymer while the other side is left unfilled. The timecourse of cartilage changes in the defect will be determined by gross grading of the joint surfaces, histological evaluation and semi-quantitative grading of MRI and X-ray images following three and six months of healing. The results of this study are expected to suggest the feasibility of this biopolymer formulation to promote articular cartilage repair. MRI is currently the only non-invasive tool for evaluating cartilage changes that is acceptable for clinical evaluations of cartilage therapies, other than self-administered patient assessments. The proposed MRI studies are important for translating findings from this animal study to the human clinical situation.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这项工作的目的是评估生物弹性聚合物作为支架的能力，并在山羊骨软骨缺损模型中支持关节软骨修复。山羊膝接受双侧手术，在股骨髁上形成一个大的软骨缺损；一侧填充定制合成的生物聚合物，而另一侧未填充。缺损软骨变化的时间进程将通过关节表面的大体分级、组织学评估以及MRI和x射线图像的半定量分级来确定，这些分级是在愈合后3个月和6个月进行的。本研究的结果有望提示这种生物聚合物配方促进关节软骨修复的可行性。MRI是目前唯一一种评估软骨变化的非侵入性工具，除了自我给药的患者评估外，它还可用于软骨治疗的临床评估。拟议的MRI研究对于将动物研究结果转化为人类临床情况非常重要。