Analysis of peptidoglycan architecture in Gram positive bacteria

革兰氏阳性菌肽聚糖结构分析

• 批准号: BB/D007534/1
• 负责人: Simon J. Foster
• 金额: $ 28.19万
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FD007534%2F1
• 关键词: Analysis; peptidoglycan; architecture; Gram; positive

The outer cell wall of bacteria is essential to hold the cells together and gives them their characteristic shapes. Peptidoglycan is the structural material responsible for maintaining cellular integrity for most bacteria and its synthesis is the site of action of some of the most important antibiotics (such as penicillin). Peptidoglycan is made of strands of sugars linked together by strings of amino acids. The structure of peptidoglycan is dynamic to allow for cell growth, division and many other features. Surprisingly we do not know how the chemical structure of the peptidoglycan leads to its final architecture, which of course is necessary for its essential functions. The project will take an integrated approach to determine the length of the sugar strands in the peptidoglycan and how this is involved in the ability of the polymer to maintain its role. The project will address a fundamental area of microbiology.

细菌的外细胞壁对于将细胞保持在一起并赋予它们特征性的形状至关重要。肽聚糖是负责维持大多数细菌细胞完整性的结构材料，其合成是一些最重要的抗生素（如青霉素）的作用部位。肽聚糖是由氨基酸链连接在一起的糖链组成的。肽聚糖的结构是动态的，以允许细胞生长、分裂和许多其他特征。令人惊讶的是，我们不知道肽聚糖的化学结构如何导致其最终结构，这当然是其基本功能所必需的。该项目将采取综合方法来确定肽聚糖中糖链的长度，以及这如何参与聚合物保持其作用的能力。该项目将涉及微生物学的一个基本领域。