Interaction of Staphylococcus aureus and humans: Iron regulated surface proteins and a novel host defence mechanism

金黄色葡萄球菌与人类的相互作用：铁调节的表面蛋白和新型宿主防御机制

• 批准号: G0600801/1
• 负责人: Simon J. Foster
• 金额: $ 40.7万
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0600801%2F1
• 关键词: Interaction; Staphylococcus; aureus; humans; Iron

Staphylococcus aureus is an important human pathogen, particularly in hospitals where it kills many people each year. The problem is compounded by the spread of antibiotic resistance and we know the organism best as MRSA (methiciliin resistant S. aureus). We have identified a number of S. aureus components that are being developed as a vaccine to prevent disease and spread of the bug. We have also found that one of these bug proteins protects it against a number of the mechanisms we humans make to defend ourselves. In doing so we have found a new way in which humans are able to turn off the toxins made by S. aureus. We will find out how this mechanism works and how the bug is able to defend itself in this battle. The research will define how the bugs and we have evolved to interact with each other and give novel potential avenues to sway the outcome in our favour.

金黄色葡萄球菌是一种重要的人类病原体，特别是在医院，它每年杀死许多人。抗生素耐药性的传播使这个问题更加复杂，我们最了解的微生物是MRSA（耐甲氧西林S。 aureus)具有良好的抗菌活性。我们已经确定了一些S。金黄色葡萄球菌的成分，这些成分被开发为疫苗，以防止疾病和病菌的传播。我们还发现，这些虫蛋白中的一种可以保护它不受我们人类为保护自己而做出的一些机制的影响。在这样做的过程中，我们发现了一种新的方法，使人类能够关闭毒素的S。金黄色。我们将了解这种机制是如何工作的，以及bug是如何在这场战斗中保护自己的。这项研究将确定虫子和我们是如何进化到相互作用的，并给出新的潜在途径来影响对我们有利的结果。