FLUORESCENT POLYMER CHEMOSENSORS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。我们一直在研究一系列新的荧光，共轭聚合物材料，含有多受体组件。多个受体位点通过共轭聚合物（分子导线）电子连接，并表现出比更传统的基于分子的荧光化学传感器更大的灵敏度增益。已发现这些聚合物在低至4 × 10-9 M的浓度下对过渡金属离子有定量响应。我们还开发了一种新的方法来创建无机/有机杂化聚合物，通过“打开”荧光机制响应。这种混合系统显示出有前途的结果，生物铁的选择性检测。为了更完整地表征荧光猝灭过程的动力学，时间分辨发射和瞬态吸收测量是必要的。鉴于这些聚合物的非线性Stern-Volmer行为，这是特别重要的，所述非线性Stern-Volmer行为可归因于聚合物主链上的能量转移动力学和更传统的静态淬灭的组合。一个具体的电子物理的目标将是确定电荷转移产品是否形成在淬火过程中。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have been investigating a new series of fluorescent, conjugated polymer materials that contain polyreceptor assemblies. The multiple receptor sites are electronically connected by the conjugated polymer (molecular wire) and exhibit larg sensitivity gains over more conventional molecule-based fluorescent chemosensors. These polymers have been found to respond quantitatively to transition metal ions at concentrations as low as 4*10-9 M. We have also developed a new method to create inorganic/organic hybrid polymers that respond through a "turn-on" fluorescence mechanism. This hybrid system is showing promising results for the selective detection of biological iron. In order to more completely characterize the dynamics of the fluorescent quenching process, time-resolved emission and transient absorption measurements are necessary. This is particularly important in light of the non-linear Stern-Volmer behavior of these polymers that can be attributed to a combination of energy transfer dynamics on the polymer backbone and more traditional static quenching. A specific photophysical goal will be to identify whether charge transfer products are formed during the quenching process.