CANCER CHEMOPREVENTIVE AND ANTIOXIDANT AGENTS FROM ALLIUM SPECIES

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本研究的目的是分离、鉴定和表征葱属植物如洋葱、大蒜和绿色洋葱中具有与人类癌症化学预防相关的生物活性的内源性成分。第二阶段酶诱导活性的测定，和一组选定的抗氧化功能或生理相关性，将分别作为主要和次要的测定，以指导从选定的葱属蔬菜提取物中分离和纯化生物活性成分。在通常消费的水果蔬菜中确定促进健康的植物化学物质，如果它们最终被证明对人类有效，将有助于农业的有效性和可持续性，并鼓励公众做出促进健康的食物选择。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this study is to isolate, identify and characterize endogenous components in Allium species, such as onion, garlic and green onion that possess biological activities relevant to cancer chemoprevention in humans. Determination of phase II enzyme inducing activity, and a set of selected antioxidant functions or physiological relevance will be used, respectively, as primary and secondary assays to direct the isolation and purification of bioactive principles from extracts of selected Allium vegetables. The identification of health-promoting phytochemicals in commonly consumed fruits vegetables, if they are ultimately shown to be efficacious in humans, will contribute to the effectiveness and sustainability of agriculture as well as encourage the public to make health-promoting food choices.