IDENTIFICATION OF DMC1 INTERACTING PROTEINS

DMC1 相互作用蛋白的鉴定

• 批准号: 7420755
• 负责人: DOUGLAS K BISHOP
• 金额: $ 0.29万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-20 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7420755
• 关键词: proteins; yeasts

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Previous biochemical characterization of the protein components of meiotic recombination complexes has been limited. Only a few components of the recombination complex have been identified and these have been studied only outside of a meiotic context following expression in mitotic yeast or E. coli. We are attempting to identify and characterize components of the meiotic recombination complex by purifying them from the normal cellular context in which they function.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。以往对减数分裂重组复合体蛋白质组分的生化表征有限。目前只鉴定了重组复合体的几个成分，这些成分只在有丝分裂酵母或大肠杆菌中表达后的减数分裂背景下进行了研究。我们正试图通过从正常的细胞环境中提纯它们来鉴定和表征减数分裂重组复合体的成分。