DE-UBIQUITINATION ENZYMES

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。泛素化和去泛素化在细胞生物学动力学中起着核心作用。本项目旨在了解一类新的去泛素化酶，它在所有生物中都是保守的。这类酶与卵巢肿瘤发生和t细胞分化有关。然而，这些去泛素化酶的两个最保守成员的功能仍然不清楚。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Ubiquitination and de-ubiquitination plays a central role in the dynamics of cell biology. This project intends to understand a novel class of de-ubiquitination enzymes, which are conserved in all organisms. Enzymes of this class have been implicated in ovarian tumorgenesis as well as T-cell differentiation. However, the functions of two most conserved members of these de-ubiquitination enzymes are still not understood.