BIOCHEMICAL ANALYSIS OF CENTROSOMAL PROTEIN COMPLEXES

中心体蛋白复合物的生化分析

• 批准号: 7420687
• 负责人: ALEXANDER DAMMERMANN
• 金额: $ 0.29万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-20 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7420687
• 关键词: centrosome; proteins

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Centrosomes are the primary microtubule organizing centers in animal cells. Our laboratory is interested in determining how centrosomes assemble and function, using C. elegans as a model. Previous work in a number of laboratories has identified ~15 proteins required for centrosome function in this organism. We are currently using biochemistry to further characterize these proteins and identify additional proteins by virtue of their interaction with known centrosomal proteins.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。中心体是动物细胞中主要的微管组织中心。我们的实验室有兴趣使用线虫作为模型来确定中心体的组装和功能。许多实验室之前的工作已经鉴定出该生物体中心体功能所需的约 15 种蛋白质。我们目前正在使用生物化学来进一步表征这些蛋白质，并通过它们与已知中心体蛋白质的相互作用来鉴定其他蛋白质。