VIRTUAL TOOLS FOR CARDIAC VENTRICULAR REMODELING SURGERY

心室重构手术的虚拟工具

• 批准号: 7385153
• 负责人: Julius Matteo Guccione
• 金额: $ 38.45万
• 依托单位: NORTHERN CALIFORNIA INSTITUTE/RES/EDU
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-15 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7385153
• 关键词: 3-Dimensional; Aneurysm; Animals; Apical Myocardial Infarction; Barium; Biomechanics; Biomedical Engineering; Blood flow; Cardiac; Cardiac Catheterization Procedures; Cardiovascular Diseases; Catheters; Cell Therapy; Cessation of life; Clinical; Computer software; Condition; Contracts; Contracture; Coronary; Coronary artery; Development; Diagnostic; Diastolic blood pressure; Diffusion Magnetic Resonance Imaging; Dobutamine; Doctor of Philosophy; Dose; Elements; Epidemic; Equation; Evaluation; Failure; Formalin; Gel; Goals; Hand; Heart; Heart failure; Hypertrophy; Image; Infarction; Knowledge; Laboratories; Laws; Lead; Left; Left Ventricular Function; Left Ventricular Mass; Ligation; Magnetic Resonance; Magnetic Resonance Imaging; Measures; Mechanics; Medical; Medical center; Medicine; Methods; Modality; Modeling; Motion; Muscle Cells; Myocardial; Myocardial Infarction; Myocardial tissue; Myocardium; Operative Surgical Procedures; Output; Oxygen Consumption; Patients; Perfusion; Personal Satisfaction; Physiologic intraventricular pressure; Preparation; Property; Pump; Research; Research Personnel; Risk; Sheep; Silicon; Simulate; Software Tools; Stress; Stroke Volume; System; Testing; Therapeutic Effect; United States; Validation; Ventricular; Ventricular Aneurysm; Ventricular Function; Ventricular Remodeling; Virtual Tool; Week; base; design; experience; gene therapy; in vivo; prevent; programs; repaired; response; simulation; success; tool

DESCRIPTION (provided by applicant): Heart failure has reached epidemic proportions in the United States and is responsible for nearly 500,000 deaths each year. The majority of heart failure cases is now the result of infarction-induced ventricular remodeling. The lack of a well-established effective treatment has lead to a continually expanding list of medical and surgical options for the palliation of heart failure patients. Unfortunately, the absence of ventricular wall motion or thickening (akinesis) can be misleading. On the other hand, through the power of computational mechanics based on the finite element (FE) method, it is possible to predict with confidence any changes in global LV function (stroke volume versus end-diastolic pressure) and regional mechanics (end-diastolic and end-systolic myofiber stress distributions) when geometric or loading conditions or myocardial material properties (diastolic stiffness and systolic contractility) are changed, thus approaching the objectives of bioengineering and deductive medicine. Broad, Long-Term Objective: Develop an easy-to-use Myocardial Material Property Software Tool (MMPST) that will enable rapid progress in cardiovascular disease research through the ability of FE models to simulate changes in global LV function and regional mechanics due to medical and/or surgical treatment. Specific Aims: 1. (A) Develop and (B) validate an MMPST that will enable cardiovascular disease researchers to easily measure regional 3-D myocardial material properties. Validation will involve both Monte Carlo simulations and a deformable silicon gel phantom that is well-described by a single material parameter. 2. Use this MMPST to: A. Measure in-vivo regional 3-D myocardial material properties in normal sheep and sheep with an akinetic or dyskinetic myocardial infarct (Ml). Dobutamine will be given to sheep with an akinetic Ml to test our hypothesis that these MIs must contain contracting myocytes. B. Measure ex-vivo regional 3-D myocardial material properties after arresting and isolating the hearts studied in Aim #2A and inflating the LV with our Vivitro servo-pump system. Additionally, biaxial mechanical testing will be performed on excised akinetic and dyskinetic MIs to further validate our MMPST.

描述（由申请人提供）：心力衰竭在美国已经达到流行病的程度，每年导致近50万人死亡。现在大多数心力衰竭病例是梗死引起的心室重构的结果。由于缺乏一种行之有效的治疗方法，治疗心力衰竭患者的内科和外科治疗方案不断扩大。不幸的是，没有心室壁运动或增厚（运动性）可能会引起误解。另一方面，通过基于有限元（FE）方法的计算力学的力量，当几何或负载条件或心肌材料特性（舒张刚度和收缩性）发生变化时，可以准确预测全局左室功能（卒中容量与舒张末期压力）和区域力学（舒张末期和收缩末期肌纤维应力分布）的任何变化。从而接近生物工程和演绎医学的目标。广泛的长期目标：开发一种易于使用的心肌材料特性软件工具（MMPST），通过有限元模型模拟医疗和/或手术治疗导致的整体左室功能和区域力学变化的能力，使心血管疾病研究取得快速进展。具体目标：1；(A)开发和(B)验证MMPST，使心血管疾病研究人员能够轻松测量区域3-D心肌材料特性。验证将包括蒙特卡罗模拟和可变形的硅胶模型，该模型可以通过单个材料参数很好地描述。2. 使用该MMPST: A.测量正常绵羊和动态或非动态心肌梗死（Ml）绵羊体内局部3-D心肌材料特性。将多巴酚丁胺与动力学Ml一起给予绵羊，以验证我们的假设，即这些mi必须包含收缩的肌细胞。B.用体外伺服泵系统对Aim #2A研究的心脏进行停搏和隔离后，测量离体区域3-D心肌材料特性。此外，将对切除的动能和非动能MIs进行双轴力学测试，以进一步验证我们的MMPST。