Simulation of Coronary Artery Bypass Graft and Surgical Ventricular Restoration

冠状动脉搭桥术和心室修复手术的模拟

• 批准号: 7915279
• 负责人: Julius Matteo Guccione
• 金额: $ 76.23万
• 依托单位: NORTHERN CALIFORNIA INSTITUTE/RES/EDU
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-15 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7915279
• 关键词: 3-Dimensional; Accounting; Address; Adopted; Adult; Affect; Algorithms; Anatomic structures; Anatomy; Anterior Descending Coronary Artery; Aorta; Architecture; Area; Arteries; Automobile Driving; Awareness; Biological; Biology; Biomechanics; Biomedical Computing; Biomedical Engineering; Biomedical Research; Biophysics; Blood Vessels; Blood capillaries; Blood flow; Bypass; Cardiac; Cardiac Surgery procedures; Cardiovascular system; Cells; Cereals; Cerebral Palsy; Cessation of life; Chemicals; Child; Code; Collaborations; Collection; Communities; Complement; Computer Assisted; Computer Simulation; Computer software; Computer-Aided Design; Copyright; Coronary; Coronary Arteriosclerosis; Coronary Artery Bypass; Coronary artery; Custom; Data; Data Analyses; Data Set; Databases; Development; Device Designs; Discipline; Disease; Doctor of Medicine; Documentation; Drug Delivery Systems; Dyskinetic syndrome; Electrophysiology (science); Electrostatics; Elements; Engineering; Ensure; Environment; Epidemic; Equation; Evaluation; Fiber; Figs - dietary; Future; Generations; Genetic Medicine; Goals; Grant; Heart; Heart failure; Human; Image; Imagery; Indiana; Individual; Infarction; Intervention; Investigation; Laboratories; Language; Lead; Left; Left Ventricular Function; Left Ventricular Remodeling; Letters; Libraries; Licensing; Life; Link; Liquid substance; Location; Logic; Magnetic Resonance Imaging; Mathematics; Mechanics; Medical; Medical Device; Medical Research; Medical center; Methodology; Methods; Mission; Modeling; Modification; Molecular; Motion; Movement; Muscle; Muscle Cells; Myocardial; Myocardial Ischemia; Myopathy; Myosin ATPase; National Center for Research Resources; Nature; Newsletter; Nonmuscle Myosin Type IIB; Operative Surgical Procedures; Organ; Organism; Paper; Parkinson Disease; Patient Care; Patients; Pattern; Performance; Persons; Pharmaceutical Preparations; Philosophy; Physics; Physiological; Physiology; Postoperative Period; Problem Solving; Procedures; Process; Prosthesis Design; Public Domains; RNA; RNA Folding; Randomized; Research; Research Infrastructure; Research Personnel; Resources; Running; Scientist; Selection Criteria; Simulate; Software Engineering; Software Tools; Solid; Solutions; Source; Source Code; Stroke; Structure; Surgeon; System; Techniques; Technology; Technology Transfer; Testing; Time; Tissues; Training; Trees; United States; United States National Institutes of Health; Universities; Validation; Vascular Diseases; Vascular System; Ventricular; Work; advanced simulation; base; biological systems; biomedical scientist; body system; capillary; commercialization; computer science; computerized tools; data modeling; design; disease diagnosis; dissemination research; effective therapy; fluid flow; graduate student; graphical user interface; hemodynamics; image visualization; improved; innovation; interest; left coronary artery; macromolecule; mathematical model; member; meter; millimeter; models and simulation; nanometer; neuromuscular; novel; novel strategies; open source; palliation; patient population; physical property; pressure; programs; randomized trial; repository; response; restoration; shear stress; simulation; software development; tool; tool development

Heart failure has reached epidemic proportions in the United States and is responsible for nearly 500,000 deaths each year. The majority of heart failure cases is now the result of infarction- induced left ventricular (LV) remodeling. The lack of a well-established effective treatment has lead to a continually expanding list of medical and surgical options for the palliation of heart failure patients. Coronary artery bypass grafting (CABG) and surgical ventricular restoration (SVR) are the two surgical options included in the ongoing $38 million NIH-sponsored multi- center randomized STICH trial (to be completed in 2008). Another recently completed randomized trial has shown for the first time a benefit of CABG + SVR over CABG alone in patients with heart failure caused by coronary artery disease. Moreover, it confirms that the SVR procedure can be performed safely in patients with severely reduced LV function. Broad, Long-Term Objective: Develop and validate a public-domain software tool that will enable clinicians to easily simulate the effects of CABG and SVR on patients with ischemic heart failure. Specific Aims: 1. Develop physics-based simulations of CABG and SVR using only public-domain software. 2. Perform pre- and post-operative CT and MRI exams on STICH patients in order to quantify their LV wall geometry and function and coronary artery anatomy and blood flow distribution. 3. Validate the simulations in Aim #1 using the LV function and coronary blood flow data acquired in Aim #2. In addition, as part of a repository for wide dissemination to the user community, CABG and SVR models will be made available via the simulation tool kit (SimTK) of Stanford's National Center for Physics-Based Simulation of Biological Structures (Simbios). These models and tools will complement work that is ongoing as part of one of the Simbios driving biological problems lead by Dr. Charley Taylor that focuses on blood flow and grafts in the aorta, and will provide a larger repertoire of fluid flow modeling capabilities in SimTK.

心力衰竭在美国已达到流行病的程度，每年造成近50万人死亡。现在大多数心力衰竭病例是梗死诱导的左心室（LV）重构的结果。由于缺乏一种行之有效的治疗方法，导致用于缓解心力衰竭患者的医疗和手术选择不断扩大。冠状动脉旁路移植术（CABG）和外科心室修复术（SVR）是正在进行的价值3800万美元的NIH赞助的多中心随机斯蒂奇试验（将于2008年完成）中包括的两种手术选择。另一项最近完成的随机试验首次显示，在冠状动脉疾病引起的心力衰竭患者中，CABG + SVR优于单纯CABG。此外，它证实了在LV功能严重降低的患者中可以安全地进行SVR手术。 广泛的长期目标：开发并验证一个公共领域的软件工具，使临床医生能够轻松模拟CABG和SVR对缺血性心力衰竭患者的影响。 具体目标：1。仅使用公共领域软件开发CABG和SVR的基于物理的模拟。2.对斯蒂奇患者进行术前和术后CT和MRI检查，以量化其LV壁几何结构和功能以及冠状动脉解剖结构和血流分布。3.使用目标#2中采集的LV功能和冠状动脉血流数据，对目标#1中的模拟进行验证。 此外，作为向用户社区广泛传播的知识库的一部分，CABG和SVR模型将通过斯坦福大学的基于物理的生物结构模拟国家中心（Simbios）的模拟工具包（SimTK）提供。这些模型和工具将补充正在进行的工作，作为Charley Taylor博士领导的Simbios驱动生物学问题之一的一部分，该问题专注于主动脉中的血流和移植物，并将在SimTK中提供更大的流体流动建模功能。

项目成果

Personalised computational cardiology: Patient-specific modelling in cardiac mechanics and biomaterial injection therapies for myocardial infarction.

• DOI: 10.1007/s10741-016-9528-9
• 发表时间: 2016-11
• 期刊: Heart failure reviews
• 影响因子: 4.6
• 作者: Sack KL;Davies NH;Guccione JM;Franz T
• 通讯作者: Franz T

Fluid-structure interaction in aortic cross-clamping: implications for vessel injury.

• DOI: 10.1016/j.jbiomech.2009.08.042
• 发表时间: 2010-01-19
• 期刊: Journal of biomechanics
• 影响因子: 2.4
• 作者: Chen HY;Navia JA;Shafique S;Kassab GS
• 通讯作者: Kassab GS

Mild anastomotic stenosis in patient-specific CABG model may enhance graft patency: a new hypothesis.

• DOI: 10.1371/journal.pone.0073769
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Huo Y;Luo T;Guccione JM;Teague SD;Tan W;Navia JA;Kassab GS
• 通讯作者: Kassab GS

Patient-specific multiscale modeling of blood flow for coronary artery bypass graft surgery.

• DOI: 10.1007/s10439-012-0579-3
• 发表时间: 2012-10
• 期刊: ANNALS OF BIOMEDICAL ENGINEERING
• 影响因子: 3.8
• 作者: Sankaran, Sethuraman;Moghadam, Mahdi Esmaily;Kahn, Andrew M.;Tseng, Elaine E.;Guccione, Julius M.;Marsden, Alison L.
• 通讯作者: Marsden, Alison L.

Simulation of mechanical environment in active lead fixation: effect of fixation helix size.

主动引线固定中的机械环境模拟：固定螺旋尺寸的影响。

• DOI: 10.1115/1.4004288
• 发表时间: 2011
• 期刊: Journal of biomechanical engineering
• 作者: Zhao,Xuefeng;Wenk,JonathanF;Burger,Mike;Liu,Yi;Das,MithileshK;Combs,William;Ge,Liang;Guccione,JuliusM;Kassab,GhassanS
• 通讯作者: Kassab,GhassanS