EVALUATION OF GUIDE TREE IMPRINTING AND PHYLOGENETIC TREE VARIATION

引导树印记和系统发育树变异的评估

• 批准号: 7367777
• 负责人: Steven E Brenner
• 金额: $ 0.77万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7367777
• 关键词: EVALUATION; GUIDE; TREE; IMPRINTING; PHYLOGENETIC

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are assessing the extent of guide tree imprinting bias in progressive multiple alignment methods across a number of alignment and phylogeny reconstruction methods. Using a guide tree independent multiple sequence alignment method, optimal with respect to its alignmment scoring model, and measures of tree topology difference we are evaluating the extent of imprinting bias in combinations of alignment and phylogeny reconstruction methods.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。我们正在通过一些比对和系统发育重建方法来评估导向树印记偏差在渐进多重比对方法中的程度。使用独立于指导树的多序列比对方法(相对于其比对评分模型而言是最优的)和树拓扑差异的度量，我们正在评估比对和系统发育重建方法组合中印记偏差的程度。