Modulation of phospholipid metabolism by annexins

膜联蛋白对磷脂代谢的调节

• 批准号: BB/D018099/1
• 负责人: Stephen Moss
• 金额: $ 46.37万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FD018099%2F1
• 关键词: Modulation; phospholipid; metabolism; annexins

Phospholipids are essential components of the human diet yet their excessive consumption, particularly in western societies is associated with obesity, diabetes and cardiovascular disease. Phospholipids are essential because they form the membranes that not only encapsulate all cells, they also form the membranes inside cells that partition cellular constituents into organelles. There are many different types of phospholipid, and these can serve both structural and signaling functions. We have observed abnormalities in a mutant mouse strain that lacks annexin 6, one of a large and abundant family of proteins that binds to phospholipids, that is strongly suggestive of defective phospholipid metabolism. The proposed research will use cells from these mice to investigate the expression and movement of certain phospholipids within these cells, and to understand how annexin 6 is involved in these activities.

磷脂是人类饮食的重要组成部分，但其过度消费，特别是在西方社会，与肥胖，糖尿病和心血管疾病有关。磷脂是必不可少的，因为它们不仅形成包裹所有细胞的膜，还形成细胞内的膜，将细胞成分分隔成细胞器。有许多不同类型的磷脂，它们可以起到结构和信号功能。我们已经观察到缺乏膜联蛋白6的突变小鼠品系中的异常，膜联蛋白6是与磷脂结合的蛋白质的大而丰富的家族之一，强烈暗示磷脂代谢缺陷。拟议的研究将使用这些小鼠的细胞来研究这些细胞内某些磷脂的表达和运动，并了解膜联蛋白6如何参与这些活动。

项目成果

Regulation of mitochondrial morphogenesis by annexin A6.

• DOI: 10.1371/journal.pone.0053774
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Chlystun M;Campanella M;Law AL;Duchen MR;Fatimathas L;Levine TP;Gerke V;Moss SE
• 通讯作者: Moss SE