RISK EVALUATION AND EDUCATION FOR ALZHEIMER'S DISEASE (REVEAL II)

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。主要假设：通过简明的教育、披露和咨询方案，确定APOE基因型披露和风险评估是否可以安全有效地提供给阿尔茨海默病（AD）患者的成年子女和兄弟姐妹。第二个假设是检查是否有任何不同类型的提供者（医生与遗传咨询师）披露APOE基因型和风险评估信息。研究人员希望发现浓缩方案与扩展方案一样安全有效，并且那些从医生或遗传咨询师那里得到结果的参与者同样满意。其他重要目的：1)确定老年AD患者亲属（60岁以下）与年轻亲属（60岁以下）对以下方面的反应是否不同：a) APOE基因分型风险评估的机会，以及(b) APOE披露和AD风险评估的经验；(2)确定AD患者的非裔美国亲属对AD患者的反应是否与欧裔美国人不同；(a)通过APOE基因分型进行风险评估的机会，以及(b) APOE披露和AD风险评估的经验。（大多数非裔美国人受试者的招募将在霍华德大学合作网站进行）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Primary Hypothesis: To determine whether APOE genotype disclosure and risk assessment may be provided safely and effectively to adult children and siblings of patients diagnosed with Alzheimer's disease (AD) through a condensed educational, disclosure and counseling protocol. A secondary hypothesis is to examine if there are any differences associated with the type of provider (physician versus genetic counselor) who discloses APOE genotype and risk assessment information. The investigators expect to find that a condensed protocol is as safe and effective as an extended protocol and those participants who receive results from a physician or genetic counselor are equally as satisfied. Other significant aims: 1) to determine whether older relatives of AD patients ( >60) respond differently than younger relatives (<age60) to: a) the opportunity for risk assessment with APOE genotyping, and (b) the experience of APOE disclosure and risk assessment for AD; (2) to determine whether African American relatives of AD patients respond differently than European Americans to; (a) the opportunity for risk assessment with APOE genotyping, and (b) the experience of APOE disclosure and risk assessment for AD. (The majority of recruitment of African American subjects will take place at the Howard University collaborating site).