RISK EVALUATION AND EDUCATION FOR ALZHEIMER'S DISEASE (REVEAL II)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 基本假设：通过精简的教育、披露和咨询程序，确定是否可以安全有效地向阿尔茨海默病(AD)患者的成年子女和兄弟姐妹提供APOE基因披露和风险评估。第二个假设是检查披露APOE基因和风险评估信息的提供者类型(医生和遗传顾问)是否有任何差异。研究人员希望发现，浓缩方案与扩展方案一样安全有效，那些从医生或遗传顾问那里收到结果的参与者也同样满意。其他重要目标：1)确定AD患者的年长亲属(&gt；60岁)对以下方面的反应是否与年轻亲属(&lt；60岁)不同：a)通过APOE基因分型进行风险评估的机会，以及(B)AD患者的APOE披露和风险评估的经验；(2)确定AD患者的非裔美国人亲属是否与欧洲美国人对此做出不同的反应；(A)通过APOE基因分型进行风险评估的机会，以及(B)AD的APOE披露和风险评估的经验。(非洲裔美国人的大部分招募工作将在霍华德大学的合作地点进行)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Primary Hypothesis: To determine whether APOE genotype disclosure and risk assessment may be provided safely and effectively to adult children and siblings of patients diagnosed with Alzheimer's disease (AD) through a condensed educational, disclosure and counseling protocol. A secondary hypothesis is to examine if there are any differences associated with the type of provider (physician versus genetic counselor) who discloses APOE genotype and risk assessment information. The investigators expect to find that a condensed protocol is as safe and effective as an extended protocol and those participants who receive results from a physician or genetic counselor are equally as satisfied. Other significant aims: 1) to determine whether older relatives of AD patients ( >60) respond differently than younger relatives (<age60) to: a) the opportunity for risk assessment with APOE genotyping, and (b) the experience of APOE disclosure and risk assessment for AD; (2) to determine whether African American relatives of AD patients respond differently than European Americans to; (a) the opportunity for risk assessment with APOE genotyping, and (b) the experience of APOE disclosure and risk assessment for AD. (The majority of recruitment of African American subjects will take place at the Howard University collaborating site).