RISK EVALUATION AND EDUCATION FOR ALZHEIMER'S DISEASE (REVEAL II)

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Primary Hypothesis: To determine whether APOE genotype disclosure and risk assessment may be provided safely and effectively to adult children and siblings of patients diagnosed with Alzheimer's disease (AD) through a condensed educational, disclosure and counseling protocol. A secondary hypothesis is to examine if there are any differences associated with the type of provider (physician versus genetic counselor) who discloses APOE genotype and risk assessment information. The investigators expect to find that a condensed protocol is as safe and effective as an extended protocol and those participants who receive results from a physician or genetic counselor are equally as satisfied. Other significant aims: 1) to determine whether older relatives of AD patients ( >60) respond differently than younger relatives (<age60) to: a) the opportunity for risk assessment with APOE genotyping, and (b) the experience of APOE disclosure and risk assessment for AD; (2) to determine whether African American relatives of AD patients respond differently than European Americans to; (a) the opportunity for risk assessment with APOE genotyping, and (b) the experience of APOE disclosure and risk assessment for AD. (The majority of recruitment of African American subjects will take place at the Howard University collaborating site).