EVALUATION OF THE ROLE OF POWER DOPPLER SONOGRAPHY IN THE DIAGNOSIS OF HEMOPH

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。血友病关节病是严重血友病最常见的并发症。目前，MRI用于诊断血液性滑膜炎(早期关节疾病)。然而，它是昂贵的，并且不提供关节滑膜炎活动性的信息-活动期疾病与非活动期疾病。能量多谱勒超声可以检测血管的变化，这对量化疾病活动是有用的。与核磁共振相比，它也很便宜，可以在没有镇静剂的情况下对儿童进行。因此，将评估其在诊断血友病滑膜炎中的作用。此外，还将研究其作为诊断早期关节疾病以预防慢性关节病的筛查工具的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hemophilic joint disease is the most common complication of severe hemophilia. Currently, MRI is used to diagnose hemoilic synovitis (early joint disease). However, it is expensive and does not give information on activity of joint synovitis-active vs inactive disease. Power doppler sonography can detect changes in vacsularity, which is useful for quantitating disease activity. It is also inexpensive compared to MRI and can be performed in children without sedation. Hence, its role in diagnosing hemophilic synovitis will be evaluated. Also, its role as a screening tool for diagnosing early joint disease to prevent chronic arthropathy will be studied.