EVALUATION OF THE ROLE OF POWER DOPPLER SONOGRAPHY IN THE DIAGNOSIS OF HEMOPH

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hemophilic joint disease is the most common complication of severe hemophilia. Currently, MRI is used to diagnose hemoilic synovitis (early joint disease). However, it is expensive and does not give information on activity of joint synovitis-active vs inactive disease. Power doppler sonography can detect changes in vacsularity, which is useful for quantitating disease activity. It is also inexpensive compared to MRI and can be performed in children without sedation. Hence, its role in diagnosing hemophilic synovitis will be evaluated. Also, its role as a screening tool for diagnosing early joint disease to prevent chronic arthropathy will be studied.