IMPACT OF THERAPEUTIC DRUG MONITORING ON VIROLOGIC RESPONSE TO A SALVAGE REGIMEN

治疗药物监测对挽救方案病毒学反应的影响

• 批准号: 7377441
• 负责人: KRISTINE B. PATTERSON
• 金额: $ 0.4万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377441
• 关键词: IMPACT; THERAPEUTIC; DRUG; MONITORING; VIROLOGIC

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will compare the effectiveness of using increased doses of protease inhibitor (PI) drugs to continuing standard doses of PIs in lowing viral load. It will also use another new monitoring tool called the normalized inhibitory quotient (NIQ). We will study the safety of increasing doses of PI drugs based on Therapeutic Drug Monitoring

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究将比较增加剂量的蛋白酶抑制剂(PI)药物与继续使用标准剂量的PI药物在降低病毒载量方面的有效性。它还将使用另一种新的监测工具，称为归一化抑制商(NIQ)。我们将在治疗药物监测的基础上研究增加PI药物剂量的安全性