MEASUREMENT OF HBNO IN VENOUS BLOOD IN HUMANS BY ELECTRON PMRS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective of this pilot study is to evaluate whether we can detect an increase in total HbNO levels in venous blood of healthy volunteers and patients with chronic heart failure using electon paramagnetic resonance spectroscopy following increasing doses of intravenous nitoplycerin trea