MEASUREMENT OF HBNO IN VENOUS BLOOD IN HUMANS BY ELECTRON PMRS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项初步研究的主要目的是评估在静脉注射硝酸甘油剂量增加后，是否可以使用电子顺磁共振波谱检测到健康志愿者和慢性心力衰竭患者静脉血中总HbNO水平的增加。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective of this pilot study is to evaluate whether we can detect an increase in total HbNO levels in venous blood of healthy volunteers and patients with chronic heart failure using electon paramagnetic resonance spectroscopy following increasing doses of intravenous nitoplycerin treatment.