INSULIN ACTION IN THE POLYCYSTIC OVARY

多囊卵巢中的胰岛素作用

• 批准号: 7376840
• 负责人: Andrea E Dunaif
• 金额: $ 0.04万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376840
• 关键词: INSULIN; ACTION; POLYCYSTIC; OVARY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Polycystic ovary syndrome (PCOS) is among the most common endocrine disorders of premenopausal women, affecting 5-10% of this population. It is the leading cause of hormonally-related infertility. Women with PCOS have elevated male hormone levels and irregular periods. They frequently have insulin resistance, conferring a seven-fold increased risk for type 2 diabetes mellitus (adult onset). PCOS is an inherited disorder. We recently discovered a genetic marker, allele 8 (A8) of D19S884, which is located on chromosome 19 near the insulin receptor. This marker is significantly associated with the PCOS reproductive phenotype. Androgen, insulin, glucose and lipid levels will be measured in all subjects. Intensive testing to examine the metabolic and lipid abnormalities associated with PCOS will be performed. Differences in insulin secretion and action, obesity risk, and metabolic response to over- and underfeeding will be compared in A8+ and A8- PCOS women as well as controls. A8+ male first-degree male relatives of PCOS women will be examined to see if they have similar metabolic alterations identified in A8+ PCOS women. Small samples of abdominal fat obtained by aspiration and mid-thigh muscle obtained by biopsy will be examined in in vitro studies of insulin sensitivity.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。多囊卵巢综合征（PCOS）是绝经前妇女最常见的内分泌疾病之一，影响5-10%的这一人群。这是导致不孕不育的主要原因。患有PCOS的女性男性激素水平升高，月经不规则。他们经常有胰岛素抵抗，使2型糖尿病（成人发病）的风险增加7倍。PCOS是一种遗传性疾病。我们最近发现了一个遗传标记，等位基因8（A8）的D19 S884，这是位于19号染色体附近的胰岛素受体。该标记物与PCOS生殖表型显著相关。 将测量所有受试者的雄激素、胰岛素、葡萄糖和脂质水平。将进行强化检测，以检查与PCOS相关的代谢和脂质异常。将比较A8+和A8- PCOS妇女以及对照组在胰岛素分泌和作用、肥胖风险以及对过度喂养和喂养不足的代谢反应方面的差异。将对PCOS女性的A8+男性一级男性亲属进行检查，以确定他们是否具有与A8+ PCOS女性相似的代谢改变。在胰岛素敏感性的体外研究中，将检查通过抽吸获得的腹部脂肪和通过活检获得的大腿中部肌肉的小样本。