OUTCOME MODIFYING GENES IN SICKLE CELL DISEASE

镰状细胞病的结果修饰基因

• 批准号: 7377422
• 负责人: Eugene P Orringer
• 金额: $ 0.02万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377422
• 关键词: OUTCOME; MODIFYING; GENES; SICKLE; CELL

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research study is to collect both clinical information and blood samples from 1000 patients at three institutions with sickle cell disease, and then to see if there are certain inherited factors (called "genes") that may modify the severity of the disease. This study seeks to find those genes that make the expression of sickle cell disease less severe and those genes that make it more severe.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这项研究的目的是从三个机构的1000名镰状细胞病患者中收集临床信息和血液样本，然后看看是否有某些遗传因素（称为“基因”）可能会改变疾病的严重程度。这项研究试图找到那些使镰状细胞病的表达不那么严重的基因和那些使其更严重的基因。