HEART RATE RECOVERY AND CARDIAC REHABILITATION

心率恢复和心脏康复

• 批准号: 7376830
• 负责人: SUSAN TIUKINHOY
• 金额: $ 0.17万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376830
• 关键词: HEART; RATE; RECOVERY; CARDIAC; REHABILITATION

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Exercise-based cardiac rehabilitation has been shown to reduce mortality and subsequent cardiac events in patients with coronary artery disease. Although the exact mechanism by which exercise reduces mortality is unclear, one hypothesis invokes the effect of exercise on autonomic tone. Recently, heart rate recovery immediately after exercise (defined as the decrease in heart rate from peak exercise to one minute into recovery) was shown to be a powerful predictor of all cause mortality. Values below twelve beats per minute were associated with a marked increase in the risk of death. Heart rate recovery is an easily measured parameter to assess autonomic tone. Although exercise training has been shown to modify the sympathovagal control of heart rate towards an increase in parasympathetic tone, no evaluation of the effect of cardiac rehabilitation on heart rate recovery has been demonstrated previously. This study aims to prospectively evaluate the effect of cardiac rehabilitation on heart rate recovery on follow-up exercise testing in patients with coronary artery disease. It also aims to evaluate the mechanism for the observed change in heart rate recovery in these patients by using parasympathetic blockade during the exercise test. If heart rate recovery does improve following a structured exercise training program, then this parameter may be useful as an outcome measure in an outpatient cardiac rehabilitation facility, and perhaps help to identify patients with increased risk for subsequent cardiac events.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。基于运动的心脏康复已被证明可以降低冠状动脉疾病患者的死亡率和随后的心脏事件。尽管运动降低死亡率的确切机制尚不清楚，但一种假设提到了运动对自主神经张力的影响。最近，运动后心率立即恢复（定义为心率从运动峰值到恢复后一分钟的下降）被证明是全因死亡率的有力预测指标。每分钟十二次以下的值与死亡风险显着增加相关。心率恢复是评估自主神经张力的一个易于测量的参数。尽管运动训练已被证明可以改变交感迷走神经对心率的控制，从而增加副交感神经的张力，但之前尚未证明心脏康复对心率恢复的影响的评估。本研究旨在前瞻性评估心脏康复对冠心病患者后续运动测试心率恢复的影响。它还旨在评估在运动测试期间使用副交感神经阻滞在这些患者中观察到的心率恢复变化的机制。如果在结构化运动训练计划后心率恢复确实有所改善，那么该参数可能可用作门诊心脏康复机构的结果测量，并且可能有助于识别后续心脏事件风险增加的患者。