HEART RATE RECOVERY AFTER EXERCISE DYNAMICAL ANALYSIS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Impaired heart rate recovery immediately after exercise has been reported to be an important, independent marker of risk. However, the optimal measures of heart rate recovery have not been determined. We are systematically comparing the ability of conventional and newer dynamical measures of heart rate recovery in different groups of subjects with heart disease as well as healthy controls. The first investigation in this project involves analysis of exercise test data from subjects with congestive heart failure in a trial of pyridostigmine, a drug which increases vagal tone. This collaborative work is supported in part by the American Heart Association, the NHLBI and the NCRR/GCRC.