ASSESSING THE PREVALENCE OF THE BK, CMV, & ADENOVIRUS INFECTIONS IN PED PTS

评估 BK、CMV 的患病率

• 批准号: 7368241
• 负责人: NEENA KAPOOR
• 金额: $ 6.64万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7368241
• 关键词: ASSESSING; PREVALENCE; BK; CMV; ADENOVIRUS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this trial is to assess the prevalence of the BK, CMV, and adenovirus in pediatric patients undergoing hematopoietic stem cell transplantation. We will perform longitude analysis of the presence and levels of BK, CMV, and adenovirus in the urine and blood of pediatric patients undergoing hematopoietic stem cell transplant (HSCT). We expect to correlate levels of BK, CMV, and adenovirus with the following: 1) underlying disease (malignant vs. genetic), 2) prior medications, 3) transplant type (sibling, unrelated donor, cord blood, haploidentical), 4) hemorrhagic cystitis or other possible BK, CMV, or adenovirus virus-related disease, 5) inter-current anti-viral therapy, 6) immune function recovery, and 7) immune suppression intensity.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本试验的目的是评估BK、CMV和腺病毒在接受造血干细胞移植的儿科患者中的患病率。我们将对接受造血干细胞移植（HSCT）的儿童患者的尿液和血液中BK、CMV和腺病毒的存在和水平进行经度分析。我们期望BK、巨细胞病毒和腺病毒的水平与以下因素相关：1)潜在疾病（恶性与遗传性），2)既往用药，3)移植类型（兄弟姐妹、非亲属供体、脐带血、单倍体），4)出血性膀胱炎或其他可能的BK、巨细胞病毒或腺病毒相关疾病，5)当前抗病毒治疗，6)免疫功能恢复，7)免疫抑制强度。