ASSESSING THE PREVALENCE OF THE BK, CMV, & ADENOVIRUS INFECTIONS IN PED PTS

评估 BK、CMV 的患病率

• 批准号: 7716731
• 负责人: NEENA KAPOOR
• 金额: $ 1.32万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-20 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716731
• 关键词: Adenovirus Infections; Adenoviruses; Blood; Childhood; Computer Retrieval of Information on Scientific Projects Database; Cystitis; Cytomegalovirus; Disease; Funding; Genetic; Grant; Hematopoietic Stem Cell Transplantation; Hematopoietic stem cells; Immune; Institution; Malignant - descriptor; Patients; Pharmaceutical Preparations; Prevalence; Purpose; Recovery; Research; Research Personnel; Resources; Siblings; Source; Stem cell transplant; Umbilical Cord Blood; United States National Institutes of Health; Urine; Viral; Virus; immune function; transplantation typing

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this trial is to assess the prevalence of the BK, CMV, and adenovirus in pediatric patients undergoing hematopoietic stem cell transplantation. We will perform longitude analysis of the presence and levels of BK, CMV, and adenovirus in the urine and blood of pediatric patients undergoing hematopoietic stem cell transplant (HSCT). We expect to correlate levels of BK, CMV, and adenovirus with the following: 1) underlying disease (malignant vs. genetic), 2) prior medications, 3) transplant type (sibling, unrelated donor, cord blood, haploidentical), 4) hemmorhagic cystitis or other possible BK, CMV, or adenovirus virus-related disease, 5) inter-current anti-viral therapy, 6) immune function recovery, and 7) immune suppression intensity.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本试验的目的是评估接受造血干细胞移植的儿科患者中BK、CMV和腺病毒的患病率。 我们将对接受造血干细胞移植（HSCT）的儿科患者的尿液和血液中BK、CMV和腺病毒的存在和水平进行纵向分析。 我们希望BK、CMV和腺病毒的水平与以下因素相关：1）基础疾病（恶性vs.遗传），2）既往用药，3）移植类型（同胞、无关供体、脐带血、单倍相合），4）出血性膀胱炎或其他可能的BK、CMV或腺病毒相关疾病，5）间流抗病毒治疗，6）免疫功能恢复，（7）免疫抑制强度。