MAPPING SITES OF PHOSPHORYLATION ON SUPPRESSOR OF CYTOKINE SIGNALING 1 (SOCS-1)

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Bypassing SOCS-1 activity may be an essential step during cellular transformation by Jak-dependent oncogenes. SOCS-1 over expression is unable to inhibit transformation by v-Abl oncogenes that suggests the activity of SOCS-1 is decreased. The Rothman laboratory has evidence that the phosphorylation of SOCS-1 on non-tyrosine residues has a role in modulating the activity of SOCS-1. The determination of the sites of phosphorylation would be very useful in understanding this important regulatory event.