DEVELOPMENT OF MR MICROCOILS FOR MICROIMAGING & SPECTROSCOPY

用于显微成像的 MR 微线圈的开发

• 批准号: 7369572
• 负责人: STEPHEN J. BLACKBAND
• 金额: $ 11.58万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7369572
• 关键词: DEVELOPMENT; MR; MICROCOILS; MICROIMAGING; SPECTROSCOPY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Microimaging and spectroscopy of very small samples requires the development of small rf coils in order to maximize the signal obtained. In accordance with Aim #1 of Core 2, we have been constructing a range of solenoidal coils for the 750MHz instrument for a range of sample ranging from single cells, alginate beads, spinal cords, muscle fibers and mouse brains, and this work has continued this year. This year has required the incorporation of perfusion with the probes, particularly for studies with our collaborators on alginate beads and islets. Additionally P31 coils have been constructed for studies of isolated muscle fibers. We have also constructed coils for operation at 13C and O17 at 4.7T, 11.1T and on the 17.6T systems. The 13C coils support studies on spectroscopy of rat tumors with Dr Mike Gamscik (Duke). The O17 is being developed in collaboration with Wei Chen for monitoring tissue oxygen consumption rate. The SNR is critical in these studies, and we are pinning our best hopes on the 17.6T magnet. To date, we have constructed a compete rf probe and probe body with an O17 coil, a separate butterfly 1H coil, and animal maintenance and monitoring. Using this probe we have obtained the first O17 CSI data and O17 images of a live mouse brain.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。对非常小的样品进行显微成像和光谱分析需要开发小的射频线圈，以便最大限度地获得信号。根据Core 2的目标#1，我们一直在为750 MHz仪器建造一系列螺线管线圈，样本范围从单细胞、藻酸盐珠、脊髓、肌肉纤维和小鼠大脑，这项工作今年仍在继续。今年需要将灌注与探针结合在一起，特别是在与我们的合作者一起研究海藻酸珠和胰岛时。此外，还构建了p31线圈，用于研究分离的肌肉纤维。我们还建造了在13C和O17、4.7T、11.1T和17.6T系统上运行的线圈。13C线圈支持迈克·伽姆西克博士(Duke)对大鼠肿瘤的光谱学研究。O17是与魏晨合作开发的，用于监测组织氧耗率。信噪比在这些研究中至关重要，我们将最大的希望寄托在17.6T的磁铁上。到目前为止，我们已经构建了一个竞争射频探头和探针体，带有一个O17线圈，一个单独的蝴蝶1H线圈，以及动物维护和监测。使用这个探针，我们已经获得了第一批O17 CSI数据和活鼠脑的O17图像。