Genotype-Environment variation in heavy metal tolerance

重金属耐受性的基因型-环境变异

• 批准号: 7339298
• 负责人: ERIC Jeremiah VON WETTBERG
• 金额: $ 4.68万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7339298
• 关键词: Agriculture; Animal Model; Arabidopsis; Biological Models; Candidate Disease Gene; Complement; Condition; Environment; Environmental Health; European; Fertility; Generations; Genes; Genetic; Genetic Drift; Genetic Polymorphism; Genetic Variation; Genome; Genomics; Genotype; Growth; Heavy Metals; Human Activities; Individual; Link; Longevity; Measures; Metabolic; Molecular Evolution; Nickel; Nutritional; Organism; Pathway interactions; Pattern; Population; Predisposition; Process; Range; Rate; Relative (related person); Severities; Soil; Stress; Testing; Thinking; Tissues; Toxic Environmental Substances; Toxic effect; Toxin; Variant; Work; cost; gene function; improved; plant growth/development; protein metabolite; tool; toxic metal; trait

Both natural processes and human activities can result in environmental toxins. The severity of toxicity varies with both expsoure to toxins and the susceptibility of particular genetic backgrounds. The evolutionary consequences of toxicity hinge on the interaction between genotypic variation and different exposure environments. The ideal model system for understanding these interactions is one where there is naturally occurring variation in susceptibility to naturally occurring toxins, such as heavy metal tolerance in Arabidopsis lyrata, the nearest relative of A. thaliana. In this systemexposureto heavy metals only occurs in a limited set of environments, and tolerance has somefitness cost, so that tolerance is not favored in all places. I will study genetic variation in heavy metal tolerance in A. lyrata through high-throughput genotyping of ecotypes from different soil types differing in heavy metal concentrations. Understanding natural variation in heavy metal tolerance, both in the presence and absence of exposure, is important to understanding evolutionary constraints on genes conferring tolerance, elucidating limits on tolerance, and for determining how tolerance can be improved in agricultural and environmental health contexts.

自然过程和人类活动都可能导致环境毒素。毒性的严重程度各不相同 既有对毒素的暴露，又有特定遗传背景的易感性。进化 毒性的后果取决于基因型变异和不同暴露之间的相互作用 环境.理解这些相互作用的理想模型系统是一个自然存在 对天然毒素的敏感性发生变化，如对重金属的耐受性， Arabidopsis lyrata是A. thaliana.在这个系统中，对重金属的吸收只发生在 一组有限的环境，宽容有一些适应性成本，所以宽容不是所有人都喜欢的。 地我将研究A.通过高通量基因分型 不同生态类型土壤重金属含量不同。理解自然变异 在重金属耐受性，无论是在存在和不存在的接触，是重要的了解 对赋予耐受性的基因的进化限制，阐明耐受性的限制，以及确定 如何在农业和环境卫生方面提高耐受性。