HDAC 1 and 5 in Periodontitis
HDAC 1 and 5 in Periodontitis
批准号:
nhmrc : GNT1057835
负责人:
Dr Melissa Cantley
金额:
$34.6万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2017-12-31
关键词:
中文摘要
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英文摘要
Bone loss and tooth loosening are serious complications in periodontitis. Despite the prevalence of this disease current treatments do not directly stop the bone loss. Our recent laboratory studies show inhibiting histone deacetylase (HDAC) activity with very low doses of inhibitors can effectively suppress this bone loss in periodontitis. This project aims to investigate specific targeting inhibitors of HDAC 1 and HDAC 5 to treat periodontitis by enhancing bone formation and reducing bone loss.
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会议论文
The effect of histone deacetylase inhibitors on the bone environment in multiple myeloma
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批准号:nhmrc : 1070880
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项目类别:Early Career Fellowships
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资助金额:$23.8万
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财政年份:2014
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负责人:Dr Melissa Cantley
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依托单位:
Targeting histone deacetylases 1 and 5 to reduce inflammation and bone loss in periodontitis.
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批准号:nhmrc : 1057835
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项目类别:Project Grants
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资助金额:$35.79万
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财政年份:2014
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负责人:Dr Melissa Cantley
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依托单位:
HDACi and bone in Multiple myeloma
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批准号:nhmrc : GNT1070880
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项目类别:Early Career Fellowships
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资助金额:$30.46万
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财政年份:2014
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负责人:Dr Melissa Cantley
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依托单位:
海外基金