The effect of histone deacetylase inhibitors on the bone environment in multiple myeloma

组蛋白脱乙酰酶抑制剂对多发性骨髓瘤骨环境的影响

• 批准号: nhmrc : 1070880
• 负责人: Dr Melissa Cantley
• 金额: $ 23.8万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/effect-histone-deacetylase-multiple-myeloma/455444
• 关键词: effect; histone; deacetylase; inhibitors; bone

Multiple myeloma (MM) is an incurable hematological malignancy with 1,400 people diagnosed each year. Severe bone loss occurs in up to 90% of these patientssignificantly impacting on quality of life resulting in severe bone pain and bone lesions that fail to heal. This project proposes that a novel histone deacetylase inhibitor could provide an appropriate therapeutic strategy that inhibits tumor growth and prevents bone loss whilst also promoting bone repair.

多发性骨髓瘤（MM）是一种无法治愈的血液恶性肿瘤，每年有1，400人被诊断。高达90%的患者发生严重的骨丢失，严重影响生活质量，导致严重的骨痛和无法愈合的骨病变。该项目提出，一种新的组蛋白去乙酰化酶抑制剂可以提供一种适当的治疗策略，抑制肿瘤生长，防止骨丢失，同时也促进骨修复。